181300-46-9

Upstream product

• 50873-94-4 (4-iodobutoxymethyl)benzene 
• 108-94-1 cyclohexanone 
• 100-39-0 benzyl bromide 
• 4541-14-4 4-benzyloxy-butan-1-ol 
• 10424-93-8 N'-cyclohexylidene-N,N-dimethyl-hydrazine 
• 60789-54-0 4-bromobutyl benzyl ether 

Downstream Products

• 181300-47-0 6-(4-Benzyloxy-butyl)-1,4-dioxa-spiro[4.5]decane 
• 211234-58-1 [2-(4-Benzyloxy-butyl)-cyclohex-1-enyloxy]-trimethyl-silane 
• 211234-69-4 [6-(4-Benzyloxy-butyl)-bicyclo[4.1.0]hept-1-yloxy]-trimethyl-silane 
• 211234-84-3 Chloro-acetic acid 6-(4-benzyloxy-butyl)-bicyclo[4.1.0]hept-1-yl ester 

Relevant academic research and scientific papers

Synthesis of Cadinanolide Type of Tricyclic α-Methylene-γ-lactone Using Intramolecular Cyclization of α-Trimethylsilylmethyl-α,β-Unsaturated Ester with Cyclic Ketone

Fluoride-promoted intramolecular cyclization of ethyl 6-(2-oxocyclohex-1-yl)-2-(trimethylsilylmethyl)hex-2-enoate afforded ethyl 2-(1-hydroxybicyclo[4.4.0]decan-2-yl)acrylate as the major product, together with tricyclic α-methylene-γ-lactone, a model compound of cadinanolides. The former product was also converted to γ-lactone. The cyclization reaction promoted by TiCl4 gave the hydroxy ester and its dehydrated product. Both Lewis acid- and fluoride-promoted cyclizations gave a trans-decaline system mainly. This stereoselectivity is completely different from that of Reformatsky cyclization observed by Dreiding and co-workers.

Enzymatic resolution of bicyclo[n.1.0]alkan-1-ols derivatives: Preparation of optically active α-substituted α-methylcycloalkanones

Optically active α-methyl α-substituted cycloalkanones are prepared by a chemoenzymatic sequence which involves a Lipozyme-catalyzed transesterification of 1-(chloroacetoxy)bicyclo[n.1.0]alkanes and ring opening of these cyclopropanol derivatives.