18135-92-7

Upstream product

• 120-72-9 indole 
• 132980-32-6 2-(1H-1,2,3-benzotriazol-1-ylmethyl)phenol 
• 1666-14-4 N’-(2-hydroxybenzylidene)-4-methylbenzene-1-sulfonohydrazide 
• 90-01-7 salicylic alcohol 

Relevant academic research and scientific papers

Dearomatization of Indoles via a Phenol-Directed Vanadium- Catalyzed Asymmetric Epoxidation and Ring-Opening Cascade

An enantioselective dearomatization of indole derivatives was realized by the complexes derived from the vanadium complex VO(acac)2 and C2-symmetric bis-hydroxamic acid (BHA) ligands. The reaction proceeded via asymmetric epoxidation

Design, step-economical diversity-oriented synthesis of an N-heterocyclic library containing a pyrimidine moiety: Discovery of novel potential herbicidal agents

The synthesis of highly diverse libraries has become of paramount importance for obtaining novel leads for drug and agrochemical discovery. Herein, the step-economical diversity-oriented synthesis of a library of various pyrimidine-N-heterocycle hybrids was developed, in which a 4,6-dimethoxypyrimidine core was incorporated into nine kinds of N-heterocycles. A total of 34 structurally diverse compounds were synthesized via a two-step process from very simple and commercially available starting materials. Further, in vivo biological screening of this library identified 11 active compounds that exhibited good post-emergence herbicidal activity against D. sanguinalis at 750 g ai per ha. More importantly, pyrimidine-tetrahydrocarbazole hybrid 5q showed good to excellent herbicidal activity against five test weeds at the same dosage. Pyrimidine-tetrahydrocarbazole hybrids represent a novel class of herbicidal agents that may become promising lead compounds in the herbicidal discovery process.

A catalytic N-deacylative alkylation approach to hexahydropyrrolo[2,3-b]indole alkaloids

A versatile unprecedented strategy to diversely functionalized hexahydropyrrolo[2,3-b]indole alkaloids is described in high chemical yields. The synthesis features a key Pd(0)-catalyzed deacylative alkylation of N-acyl 3-substituted indoles using only 1 mol% of Pd(PPh3)4. The scope of this methodology is further defined in the asymmetric synthesis of pyrroloindolines using a diastereoselective approach.

Iron-Catalyzed Direct C3-Benzylation of Indoles with Benzyl Alcohols through Borrowing Hydrogen

We present the coupling of primary and secondary benzyl alcohols with indoles to form 3-benzylated indoles and H2O that is catalyzed, for the first time, by a complex of earth-abundant iron. This transformation accommodates a variety of substrates and is distinguished by its operational simplicity, sustainability, high functional-group tolerance, and amenability to gram-scale synthesis. On the basis of the preliminary experimental observations, we propose that the reaction proceeds through a borrowing hydrogen process.

Reactions of indoles with 2- and 4-hydroxybenzyl alcohols

A procedure has been proposed for the synthesis of 1H-indolylmethylphenols by reaction of hydroxybenzyl alcohols with indoles under conditions implying thermal generation of o- and p-methylenequinones. The mechanism of formation and spectral parameters of the products are discussed.

o-(α-Benzotriazolylalkyl)phenols: Novel Precursors for the Preparation of 1,1-Bis(2-hydroxyaryl)alkanes

Reactions of o-(α-benzotriazolylalkyl)phenols with a variety of substituted phenols and naphthols in the presence of a base provide efficient access to symmetrical and more importantly to unsymmetrical 1,1-bis(2-hydroxyaryl)alkanes.