18141-38-3

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 770-10-5 benzyltrichlorosilane 
• 928-65-4 hexyltrichlorosilane 
• 5283-66-9 octyltrichlorosilane 
• 1558-25-4 (chloromethyl)trichlorosilane 
• 108-90-7 chlorobenzene 

Downstream Products

• 1172-90-3 4-chlorophenyltriphenylsilylketone 
• 1174-53-4 Triphenyl-<4-chlor-α.α-dibrom-benzyl>-silan 
• 17876-99-2 (4-chlorobenzyl)trimethylsilane 

Relevant academic research and scientific papers

Potassium Alkylpentafluorosilicates, Primary Alkyl Radical Precursors in the C-1 Alkylation of Tetrahydroisoquinolines

In this study, we demonstrate that potassium alkylpentafluorosilicates (RSiF5K2) are efficient primary alkyl radical precursors for selective C(sp3)-C(sp3) bond-forming reactions. RSiF5K2 reagents are white, free-flowing solids and are moisture and air stable. This class of reagents enables the direct C-1 alkylation of tetrahydroisoquinolines under mild conditions via single-electron transfer. The broad substrate scope of both alkylpentafluorosilicates and tetrahydroisoquinolines is tolerated in this transformation. Both radical scavenger and EPR capture experiments show that the primary radical is generated by the oxidation of RSiF5K2. A mechanism involving alkyl radical addition to an iminium salt followed by reduction by an amine is proposed.

PROCESS FOR PREPARING ORGANOCHLOROSILANES BY DEHYDROHALOGENATIVE COUPLING REACTION OF ALKYL HALIDES WITH CHLOROSILANES

The present invention relates to a process for preparing organochlorosilanes and more particularly, to the process for preparing organochlorosilanes of formula I by a dehydrohalogenative coupling of hydrochlorosilanes of formula II with organic halides of formula III in the presence of quaternary phosphonium salt as a catalyst to provide better economical matter and yield compared with conventional methods, because only catalytic amount of phosphonium chloride is required and the catalyst can be separated from the reaction mixture and recycled easily, wherein R1 represents hydrogen, chloro, or methyl; X represents chloro or bromo; R2 is selected from the group consisting of C1-17 alkyl, C1-10 fluorinated alkyl with partial or full fluorination, C2-5 alkenyl, silyl containing alkyl group represented by (CH2)nSiMe3-mClm wherein n is an integer of 0 to 2 and m is an integer of 0 to 3, aromatic group represented by Ar(R′)q wherein Ar is C6-14 aromatic hydrocarbon, R′ is C1-4 alkyl, halogen, alkoxy, or vinyl, and q is an integer of 0 to 5, haloalkyl group represented by (CH2)pX wherein p is an integer of 1 to 9 and X is chloro or bromo, and aromatic hydrocarbon represented by ArCH2X wherein Ar is C6-14 aromatic hydrocarbons and X is a chloro or bromo; R3 is hydrogen, C1-6 alkyl, aromatic group represented by Ar(R′)q wherein Ar is C6-14 aromatic hydrocarbon, R′ is C1-4 alkyl, halogen, alkoxy, or vinyl, and q is an integer of 0 to 5; and R4 in formula I is the same as R2 in formula III and further, R4 can also be (CH2)pSiR1Cl2 or ArCH2SiR1Cl2, when R2 in formula III is (CH2)pX or ArCH2X, which is formed from the coupling reaction of X—(CH2)p+1—X or XCH2ArCH2X with the compounds of formula II; or when R2 and R3 are covalently bonded to each other to form a cyclic compounds of cyclopentyl or cyclohexyl group, R3 and R4 are also covalently bonded to each other in the same fashion.

Process for preparing organochlorosilanes by dehydrohalogenative coupling reaction of alkyl halides with chlorosilanes

The present invention relates to a process for preparing organochlorosilanes and more particularly, to the process for preparing organochlorosilanes of R4R3CHSiR1Cl2(I) by a dehydrohalogenative coupling of hydrochlorosilanes of HSiR1Cl2(II) with organic halides of R2R3CHX (III) in the presence of quaternary phosphonium salt as a catalyst to provide better economical matter and yield compared with conventional methods, because only a catalytic amount of phosphonium chloride is required and the catalyst can be separated from the reaction mixture and recycled easily.

Dehydrohalogenative coupling reaction of organic halides with silanes

The present invention relates to methods for making the compounds of formula I which is a dehydrohalogenative coupling of hydrochlorosilanes of formula II with organic halides of formula III in the presence of a Lewis base catalyst. R3CH2SiR1Cl2??(I) HSiR1Cl2??(II) R2CH2X??(III) In formulas I and II, R1represents a hydrogen, chloro, or methyl; in formula III, X represents a chloro or bromo; in formula III, R2can be selected from the group consisting of a C1-17alkyl, a C1-10fluorinated alkyl with partial or full fluorination, a C1-5alkenyl groups, a silyl group containing alkyls, (CH2)nSiMe3-mClmwherein n is 0 to 2 and m is 0 to 3, aromatic groups, Ar(R′)1wherein Ar is C6-14aromatic hydrocarbon, R′ is a C1-4alkyl, halogen, alkoxy, or vinyl, and q is 0 to 5, a haloalkyl group, (CH2)pX wherein p is 1 to 9 and X is a chloro or bromo; or an aromatic hydrocarbon, Ar CH2X wherein Ar is C6-14aromatic hydrocarbon and X is a chloro or bromo. in formula I, R3is the same as R2in formula III and further, R3can also be (CH2)pSiR1Cl2or ArCH2SiR1Cl2when R2in formula III is (CH2)pX or ArCH2X, because of the coupling reaction of X with the compound of formula II.