181418-30-4

Basic information

• Product Name: 2-(1-phenyl-1H-1,2,4-triazol-3-yloxy)ethanol
• Synonyms: 2-(1-phenyl-1H-1,2,4-triazol-3-yloxy)ethanol
• CAS NO: 181418-30-4
• Molecular Weight: 205.216
• Mol File: 181418-30-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1-phenyl-1H-1,2,4-triazol-3-yloxy)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-phenyl-1H-1,2,4-triazol-3-yloxy)ethanol(181418-30-4)
• EPA Substance Registry System: 2-(1-phenyl-1H-1,2,4-triazol-3-yloxy)ethanol(181418-30-4)

Safety Data

• Hazardous Substances Data: 181418-30-4(Hazardous Substances Data)

Upstream product

• 4231-68-9 3-hydroxy-1-phenyl-1,2,4-1H-triazole 
• 540-51-2 2-bromoethanol 

Downstream Products

• 1332370-83-8 2-(1-phenyl-1H-1,2,4-triazol-3-yloxy)ethanol hydrochloride 

Relevant articles and documents

Synthesis of novel halobenzyloxy and alkoxy 1,2,4-triazoles and evaluation for their antifungal and antibacterial activities

A new class of halobenzyloxy or alkoxy 1,2,4-triazoles and their hydrochlorides were synthesized through cyclization starting from commercially available phenylhydrazine. The structures were characterized by MS, IR and 1H NMR spectra as well as elemental analyses. All the synthesized compounds were screened for their antibacterial activities in vitro against Staphylococcus aureus (ATCC29213), methicillin-resistant Staphylococcus aureus (N315), Bacillus subtilis, Escherichia coli (ATCC25922), Pseudomonas aeruginosa, Shigella dysenteriae, Eberthella typhosa, and antifungal activities against Candida albicans (ATCC76615), Aspergillus fumigatus by broth microdilution assay method. The results of preliminary bioassay indicated that 3-(2,4- difluorobenzyloxy)-1-phenyl-1H-1,2,4-triazole hydrochloride exhibited the best inhibitory activity with an MIC value of 56.25 μM against P. aeruginosa superior to Chloramphenicol, and showed comparable activity with Chloramphenicol against E. coli (ATCC25922).