181470-30-4Relevant academic research and scientific papers
Mechanistic aspects of the C-H alkynylation reaction of acetylenic triflones. Determination of phenyl versus cyclohexyl migratory aptitude for a vinylidine carbene
Xiang, Jason S.,Fuchs
, p. 5269 - 5272 (1996)
13C-2 labeled phenyl ethynyl triflone undergoes regiospecific C-H alkynylation upon reaction with cyclohexane. The 13C label is found to be exclusively adjacent to the phenyl group in the product phenyl cyclohexyl acetylene, consistent with cyclohexyl radical addition at the α-position. Control studies show preferential phenyl migration from a vinylidine carbene, thus excluding the presence of such an intermediate.
Copper-Catalyzed Trifluoromethylalkynylation of Isocyanides
Lei, Jian,Wu, Xiaoxing,Zhu, Qiang
supporting information, p. 2322 - 2325 (2015/06/02)
The title reaction proceeds with acetylenic triflones and isocyanides under mild conditions using copper as a catalyst. This transformation provides an efficient access to (E)-N-alkyl trifluoromethyl alkynyl ketoimines, which are useful building blocks for the synthesis of CF3-containing N-heterocycles, propargylamines, etc.
