1815-99-2Relevant articles and documents
Cobaloxime-Mediated Radical Alkyl-Heteroaromatic Substitution
Branchaud, Bruce P.,Choi, Youngshin Lee
, p. 4638 - 4641 (1988)
The first examples of cobaloxime-mediated radical alkyl-heteroaromatic cross-coupling, replacing a C-H in the protonated heteroaromatic with a C-alkyl, are accomplished via anaerobic visible light photolysis of 95percent EtOH solutions of primary and secondary alkyl cobaloximes, RCoIII(dmgH)2py (dmgH = dimethylglyoxime monoanion), and pyridinium, quinolinium, 4-methylpyridinium, benzothiazolium, and benzimidazolium p-toluenesulfonate.
Nickel-catalyzed alkylative cross-coupling of anisoles with grignard reagents via C-O bond activation
Tobisu, Mamoru,Takahira, Tsuyoshi,Morioka, Toshifumi,Chatani, Naoto
supporting information, p. 6711 - 6714 (2016/06/14)
We report nickel-catalyzed cross-coupling of methoxyarenes with alkylmagnesium halides, in which a methoxy group is eliminated. A wide range of alkyl groups, including those bearing β-hydrogens, can be introduced directly at the ipso position of anisole derivatives. We demonstrate that the robustness of a methoxy group allows this alkylation protocol to be used to synthesize elaborate molecules by combining it with traditional cross-coupling reactions or oxidative transformation. The success of this method is dependent on the use of alkylmagnesium iodides, but not chlorides or bromides, which highlights the importance of the halide used in developing catalytic reactions using Grignard reagents.
4-ALKYL SUBSTITUTED PYRIDINES AS ODIFEROUS SUBSTANCES
-
, (2010/06/14)
The present invention primarily concerns certain 4-alkyl pyridines of the following formula (I), wherein R is C8-C12 alkyl, odiferous substance mixtures and aromatic substance mixtures containing these 4-alkyl pyridines, the respective uses thereof as an odiferous or aromatic substance (mixture) and corresponding perfumed products.