181510-11-2Relevant academic research and scientific papers
A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABA(B) agonists and their fragmentation to 3-aminopropanesulfinic acid
Shue, Ho-Jane,Chen, Xiao,Blythin, David J.,Carruthers, Nicholas I.,Spitler, James M.,Wong, Shing-Chun,Chapman, Richard W.,Rizzo, Charles,West, Robert,She, Hoyan S.
, p. 1709 - 1714 (2007/10/03)
A series of 3-amino-N-hydroxypropanesulfonamide analogs were prepared. Several compounds showed potent binding at the GABA(B) receptor and were active in an in vitro functional assay. The GABA(B) activity of these compounds appeared to be due to the fragmented product, 3-aminopropanesulfinic acid.
