181512-33-4Relevant academic research and scientific papers
Novel syntheses of camptothecin alkaloids. Part I. Intramolecular [4 + 2] cycloadditions of N-arylimidates and 4H-3,1-benzoxazin-4-ones as 2-aza-1,3-dienes
Fortunak, Joseph M.D.,Mastrocola, Antonietta R.,Mellinger, Mark,Sisti, Nicolas J.,Wood, Jeffery L.,Zhuang, Zhi-Ping
, p. 5679 - 5682 (2007/10/03)
The first reported intramolecular [4 + 2] cycloadditions of both N-arylimidates and 4H-3,1-benzoxazin-4-ones acting as 2-aza-1,3-dienes are described. Reaction with unactivated alkynes leads to pyrrolo[3,4-b]quinolines which constitute the ABC ring system of camptothecins.
