181513-65-5

Usage

Uses

Used in Pharmaceutical Industry:
Pyrrolidine, 1-(2-phenyl-1-selenoxo-4-pentenyl)is used as a potential therapeutic agent for its antioxidant and anti-inflammatory properties. The selenoxide nature of the compound suggests that it may play a role in combating oxidative stress and inflammation, which are common targets for drug development in treating various diseases and conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, Pyrrolidine, 1-(2-phenyl-1-selenoxo-4-pentenyl)is utilized as a subject for further research to explore its unique chemical and biological properties. Pyrrolidine, 1-(2-phenyl-1-selenoxo-4-pentenyl)-'s structure may offer insights into the design of new drugs with improved efficacy and selectivity, particularly in the areas of antioxidant and anti-inflammatory therapies.

Upstream product

• 123-75-1 pyrrolidine 
• 106-95-6 allyl bromide 
• 536-74-3 phenylacetylene 

Downstream Products

• 26965-15-1 3-phenylhex-5-en-2-one 

Relevant academic research and scientific papers

Highly efficient one-pot synthesis of α,α-disubstituted selenoamides and their first reduction to amines

α,α-Disubstituted selenoamides are synthesized from terminal acetylenes, selenium, amines and allylic bromides in good to high yields; their reduction with LiAlH4 affords alkenylamines quantitatively.

An Efficient Synthetic Method of 4-Penteneselenoamides: Four-Component Coupling Reaction of Terminal Acetylenes, Selenium, Amines, and Allylic Bromides

The reaction of lithium alkyneselenolates generated from terminal acetylenes, butyllithium, and selenium with amines and allylic bromides proceeded smoothly in THF at 67°C to give 4-penteneselenoamides in moderate to high yields. The reaction may proceed via selenoketene intermediates bearing an allylic group, followed by the attack of amines to give the products. Aliphatic and aromatic acetylenes, silylacetylene, and enynes were employed as terminal acetylenes. One molar amount of secondary amines was effective, whereas an excess of primary amines was necessary. The reactions with 2-hulenyl bromide exhibited high regioselectivity, although they gave the stereoisomeric mixtures. The reactions of silyl ethers of propargylic alcohols gave α,β-unsaturated selenoamides as a product.