181517-91-9Relevant academic research and scientific papers
Asymmetric synthesis of β-fluoroaryl-β-amino acids
Davies, Stephen G.,Fletcher, Ai M.,Lv, Linlu,Roberts, Paul M.,Thomson, James E.
, p. 910 - 925 (2012/09/22)
The conjugate addition of lithium (R)-N-benzyl-N-(α-methylbenzyl) amide to a range of β-fluoroaryl-α,β-unsaturated esters gave the corresponding β-amino esters with high diastereoselectivity and in good isolated yields. Sequential treatment of the resulta
Asymmetric synthesis of β-haloaryl β-amino acid derivatives
Bull, Steven D.,Davies, Stephen G.,Delgado-Ballester, Santiago,Kelly, Peter M.,Kotchie, Luke J.,Gianotti, Massimo,Laderas, Mario,Smith, Andrew D.
, p. 3112 - 3121 (2007/10/03)
Lithium N-benzyl-N-α-methyl-4-methoxybenzylamide may be employed as a homochiral ammonia equivalent for the synthesis of homochiral β-haloaryl β-amino acid derivatives via a strategy involving its conjugate addition to α,β-unsaturated β-haloaryl acceptors and subsequent oxidative deprotection with ceric ammonium nitrate.
