181585-07-9

Basic information

• Product Name: 3-broMo-5-(2-Methoxyethoxy)pyridine
• Synonyms: 3-broMo-5-(2-Methoxyethoxy)pyridine
• CAS NO: 181585-07-9
• Molecular Formula: C₈H₁₀BrNO₂
• Molecular Weight: 232.0745
• Mol File: 181585-07-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-broMo-5-(2-Methoxyethoxy)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-broMo-5-(2-Methoxyethoxy)pyridine(181585-07-9)
• EPA Substance Registry System: 3-broMo-5-(2-Methoxyethoxy)pyridine(181585-07-9)

Safety Data

• Hazardous Substances Data: 181585-07-9(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-(2-methoxyethoxy)pyridine is a chemical compound with the molecular formula C9H10BrNO2. It is a pyridine derivative that contains a bromine atom and a 2-methoxyethoxy substituent. 3-broMo-5-(2-Methoxyethoxy)pyridine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in chemical research and in the production of other organic compounds. The presence of the bromine atom and the methoxyethoxy group in its structure gives 3-bromo-5-(2-methoxyethoxy)pyridine unique chemical properties and reactivity, making it a valuable building block for the creation of more complex organic molecules. It is important to handle this compound with caution, as it may pose health and environmental hazards.

Upstream product

• 74115-13-2 5-bromopyridine-3-ol 
• 6482-24-2 2-Bromoethyl methyl ether 
• 625-92-3 3,5-dibromopyridine 
• 109-86-4 2-methoxy-ethanol 

Downstream Products

• 1010104-34-3 5-(2-methoxyethoxy)-3-pyridineboronic acid pinacol ester 
• 1462279-11-3 1,4-bis(5-(2-methoxyethoxy)-pyridine-3-yl)benzene 
• 1383744-66-8 C₂₁H₂₃F₂N₅O₄S 

Relevant articles and documents

Structure and properties of 3-(Diethylboryl)pyridines

3-(Diethylboryl)pyridine (1a), a versatile starting material for the preparation of arylpyridines, is notable for its stability under ambient conditions, in spite of little steric hindrance on the boron atom. 1H and 13C spectra of 1a indicated that the boryl group does not act as a mere π-acceptor and that the boron atom is shielded by ca. 50 ppm even when compared with trivalent boron atoms conjugated with the π-donor. A single-crystal X-ray crystallographic study for 1a revealed formation of a cyclic-tetramer with a void via the intermolecular boron-nitrogen coordination bond. Vapor pressure osmometry in various solvents suggested that 1a comprises the tetramer in these solutions. In order to know the actual structure, synthesis of 3-(2-methoxyethoxy)-5-(diethylboryl)pyridine (1b) and its scrambling experiment with 1a were carried out. Heating at 100 °C for 24 h was required to attain the equilibrium of the scrambling of the component molecules in the tetramers. This means that 3-(diethylboryl)pyridines 1a and 1b comprise the rigid cyclic-tetramer in solution at ambient temperature. Compound 1b is stable in aerated tetrahydrofuran containing up to 33 % water.

Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors

The present invention encompasses compounds of general formula (I) wherein the groups R2 to R4, A, X and m are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain compounds of this kind and their use as medicaments.

FUSED BICYCLIC COMPOUNDS AS INHIBITORS FOR PI3 KINASE

The invention relates to compounds of formula (I) for the regulation of phosphoinositides 3-kinases activity and related diseases.