181629-57-2

Basic information

• Product Name: 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester
• Synonyms: 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester;4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid t-Butyl Ester
• CAS NO: 181629-57-2
• Molecular Formula: C₃₀H₄₀N₂O₆
• Molecular Weight: 524.65
• Product Categories: Aliphatics;Aromatics;Heterocycles
• Mol File: 181629-57-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Refractive Index: 1.569
• Solubility: Dichloromethane, Diethyl Ether, Methanol
• CAS DataBase Reference: 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester(181629-57-2)
• EPA Substance Registry System: 4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester(181629-57-2)

Safety Data

• Hazardous Substances Data: 181629-57-2(Hazardous Substances Data)

Usage

Chemical Properties

Colourless Liquid

Uses

4-[[5-Oxo-5-(phenylmethoxy)pentyl][(phenylmethoxy)carbonyl]amino]-1-piperidinecarboxylic Acid t-Butyl Ester (cas# 181629-57-2) is a compound useful in organic synthesis.

InChI:InChI=1/C30H40N2O6/c1-30(2,3)38-28(34)31-20-17-26(18-21-31)32(29(35)37-23-25-14-8-5-9-15-25)19-11-10-16-27(33)36-22-24-12-6-4-7-13-24/h4-9,12-15,26H,10-11,16-23H2,1-3H3

Upstream product

• 100-51-6 benzyl alcohol 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 181629-63-0 4-[Benzyloxycarbonyl-(4-benzyloxycarbonyl-butyl)-amino]-piperidine-1-carboxylic acid (S)-4,11-diethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-9-yl ester 
• 181629-60-7 5-[Benzyloxycarbonyl-(1-chlorocarbonyl-piperidin-4-yl)-amino]-pentanoic acid benzyl ester 

Relevant articles and documents

Semisynthesis of RPR 121056A, a major metabolite of irinotecan (CPT-11)

The semisynthesis of RPR 121056A (4), a major metabolite of irinotecan (CPT-11, 2) is reported starting from SN-38 (3) and an appropriate side-chain precursor, and using a 2-step sequence. This semisynthesis is based on the 10-O-acylation of SN-38 with the conveniently protected carbamoylchloride derivative 10 followed by cleavage of the benzylic protecting groups by hydrogenolysis. Preliminary in vitro results show that RPR 121056A displays no cytotoxicity.