181641-74-7

Basic information

• Product Name: 1,4-BIS(PHENYLMETHYL)-4-PIPERIDINECARBOXYLIC ACID
• Synonyms: 1,4-BIS(PHENYLMETHYL)-4-PIPERIDINECARBOXYLIC ACID;1,4-Bis-benzyl-4-piperidinecarboxylic acid
• CAS NO: 181641-74-7
• Molecular Formula: C₂₀H₂₃NO₂
• Molecular Weight: 309.407
• Mol File: 181641-74-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,4-BIS(PHENYLMETHYL)-4-PIPERIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-BIS(PHENYLMETHYL)-4-PIPERIDINECARBOXYLIC ACID(181641-74-7)
• EPA Substance Registry System: 1,4-BIS(PHENYLMETHYL)-4-PIPERIDINECARBOXYLIC ACID(181641-74-7)

Safety Data

• Hazardous Substances Data: 181641-74-7(Hazardous Substances Data)

Usage

Chemical class

Piperidinecarboxylic acids

Composition

Piperidine ring with two phenylmethyl groups attached at the 1 and 4 positions

Industry use

Pharmaceutical industry as a building block for drug synthesis

Known properties

Potential antihypertensive and antiarrhythmic properties

Research focus

Treatment of neurological disorders and neurodegenerative diseases

Pharmacological potential

Significant due to its various therapeutic applications

Ongoing research

Further exploration of its therapeutic applications and properties

Downstream Products

• 1143582-75-5 C₂₀H₂₄N₂O 

Relevant articles and documents

The design and discovery of novel amide CCR5 antagonists

The synthesis of a range of novel amine-containing structures and their primary potency as inhibitors of HIV-1 fusion via blocking of the CCR5 receptor is described. The development of the medicinal chemistry strategy and SAR's which led to the identification of the piperidine amide compounds 33 and 36 as excellent leads for further evaluation is described, along with key physicochemical data which highlighted their lead potential.

PIPERIDINE DERIVATIVES, PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Piperidine derivatives, process for obtaining them and pharmaceutical compositions containing them, of formula STR1 used as neurokinin receptor antagonists, which are, in particular, useful for the treatment of all substance P-and neurokinin-dependent pathologies.