181650-60-2Relevant academic research and scientific papers
Structure-activity relationships for the binding of arylpiperazines and arylbiguanides at 5-HT3 serotonin receptors
Dukat, Malgorzata,Abdel-Rahman, Ashraf A.,Ismaiel, Abd M.,Ingher, Stacy,Teitler, Milt,Gyermek, Laszlo,Glennon, Richard A.
, p. 4017 - 4026 (2007/10/03)
Arylpiperazines are nonselective agents that bind at 5-HT3 serotonin receptors with moderate to high affinity, whereas 1-phenylbiguanide is a low- affinity but more selective 5-HT3 agonist. In an attempt to enhance the affinity of th
