181653-63-4Relevant academic research and scientific papers
L-Dopa process and intermediates
-
, (2008/06/13)
A process for the preparation of 3-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA) wherein α-acetamido-4-hydroxy-3-alkoxy-cinnamic acid acetate is subjected to catalytic asymmetric hydrogenation to yield an optically active mixture N-acetyl-3-(4-hydroxy-3-alkoxyphenyl)-alanine acetate, with the L enantiomorph being present in a major amount and the D enantiomorph being present in a minor amount, from which N-acetyl-3-(4-hydroxy-3-alkoxyphenyl)-L-alanine acetate can be easily recovered and is then converted to L-DOPA. Novel precursors for L-DOPA are prepared in the process of this invention.
