54835-97-1Relevant academic research and scientific papers
Stereoselective Synthesis of P-Stereogenic N-Phosphinyl Compounds
Chelouan, Ahmed,Recio, Roco,lvarez, Eleuterio,Khiar, Noureddine,Fernndez, Inmaculada
, p. 255 - 259 (2016/02/14)
A number of P-stereogenic N-phosphinyl compounds were stereoselectively prepared in good yields by a straightforward approach, thanks to the diversified and, up until now, unexplored reactivity of (R)- and (S)-dicyclohexylidene-D-glucose methyl phenyl pho
Efficient asymmetric synthesis of structurally diverse p-stereogenic phosphinamides for catalyst design
Han, Zhengxu S.,Zhang, Li,Xu, Yibo,Sieber, Joshua D.,Marsini, Maurice A.,Li, Zhibin,Reeves, Jonathan T.,Fandrick, Keith R.,Patel, Nitinchandra D.,Desrosiers, Jean-Nicolas,Qu, Bo,Chen, Anji,Rudzinski, Diandra M.,Samankumara, Lalith P.,Ma, Shengli,Grinberg, Nelu,Roschangar, Frank,Yee, Nathan K.,Wang, Guijun,Song, Jinhua J.,Senanayake, Chris H.
supporting information, p. 5474 - 5477 (2015/04/27)
The use of chiral phosphinamides is relatively unexplored because of the lack of a general method for the synthesis. Reported herein is the development of a general, efficient, and highly enantioselective method for the synthesis of structurally diverse P-stereogenic phosphinamides. The method relies on nucleophilic substitution of a chiral phosphinate derived from the versatile chiral phosphinyl transfer agent 1,3,2-benzoxazaphosphinine-2-oxide. These chiral phosphinamides were utilized for the first synthesis of readily tunable P-stereogenic Lewis base organocatalysts, which were used successfully for highly enantioselective catalysis.
Diastereoselective alkynylation of chiral phosphinoylimines: preparation of optically active propargylamines
Benamer, Mounira,Turcaud, Serge,Royer, Jacques
scheme or table, p. 645 - 648 (2010/04/23)
Chiral phosphinoylimines were prepared from methylphenylphosphonamides and tested as new chiral and activated imines. The addition of aluminum acetylides was proved to be highly diastereoselective while lithium or magnesium acetylides gave poor results. T
