18168-40-6

Usage

Appearance

White, crystalline substance

Molecular weight

178.27 g/mol

Function

Potent intravenous sedative-hypnotic agent

Used for

General anesthesia and sedation in medical procedures

Mechanism of action

Enhances the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to sedative and anesthetic effects

Administration

Intravenous

Onset of action

Rapid

Duration of action

Short

Side effects

Respiratory depression, hypotension, and potential for abuse

Clinical use

Widely used for its rapid and reliable sedative and hypnotic effects, despite drawbacks.

InChI:InChI=1/C15H16O/c1-15(2,12-8-4-3-5-9-12)13-10-6-7-11-14(13)16/h3-11,16H,1-2H3

Upstream product

• 98-83-9 isopropenylbenzene 
• 108-95-2 phenol 
• 617-94-7 1-methyl-1-phenylethyl alcohol 

Downstream Products

• 165450-61-3 2-hydroxy-3-(1-methyl-1-phenylethyl)benzaldehyde 
• 101153-03-1 Cumylphenyl Phosphite 
• 1009103-96-1 2-(2-phenylprop-2-yl)-4-tritylphenol 
• 1582788-13-3 bis[4-bromo-2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)phenoxy]titanium(IV) dichloride 
• 1582788-12-2 bis[2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)-4-chlorophenoxy]titanium(IV) dichloride 
• 1421313-43-0 bis[2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)phenoxy]titanium(IV) dichloride 
• 1582788-00-8 4-bromo-2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)phenol 
• 1582787-99-2 2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)-4-chlorophenol 
• 1582787-95-8 2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)phenol 
• 1582787-87-8 5-bromo-2-hydroxy-3-(2-phenylpropan-2-yl)benzaldehyde 
• 861903-33-5 2-hydroxy-3-(2-phenylpropan-2-yl)-5-chlorobenzaldehyde 

Relevant academic research and scientific papers

Synthesis of salicylaldehydes bearing bulky substituents in the positions 3 and 5

Reaction of 2,4-disubstituted phenols with paraformaldehyde in the presence of SnCl4 and 2,6-lutidine afforded a number of new salicylaldehydes, containing bulky substituents (tert-butyl, 1-phenylethyl, 1-(4-tert- butylphenyl)ethyl, α-cumyl, and trityl) in the positions 3 and 5.

Synthesis of 4-tert-octylphenol and 4-cumylphenol by metal triflate and metal triflimidate catalysts

Metal inflates and metal triflimidates are shown to catalyse efficiently the Friedel-Crafts alkylation of phenol with alkenes. Bismuth, copper and scandium triflates lead to very good yields with excellent para-selectivities.

Process for preparing para-cumylphenol

A process for preparing p-cumylphenol which comprises reacting phenol and α-methylstyrene in the presence of an inorganic solid acid catalyst having an acid point of an acid strength Ho of up to -3, for example activated clay, and recovering the aimed p--cumylphenol from the reaction mixture thus obtained by distilling the same while introducing an inert gas such as nitrogen and/or steam into the distillation system is disclosed. The p-cumylphenol thus obtained has a high purity and an improved color compared with those obtained by conventional methods.

ALKYLATION OF PHENOL BY ALCOHOLS IN THE PRESENCE OF ALUMINUM PHENOLATE

The reaction of phenol with alcohols in the presence of aluminum phenolate leads to a mixture of 2- and 4-alkylphenols, of which the former predominate in the case of benzyl, tert-butyl, and cyclohexyl alcohols, and the latter in the case of dimethylphenyl- and diphenylmethylcarbinols.Only triphenyl(4-hydroxyphenyl)methane is formed during the alkylation of phenol by triphenylcarbinol.In individual experiments the formation of small amounts of alkyl phenyl ethers and 2,6-dialkylphenols was observed.

Phenol transalkylation process

Phenols having an unsubstituted ortho position are transalkylated in the ortho position by mixing them with an ortho-alpha-branched alkylphenol (e.g., 2,6-di-sec-butylphenol) and an aluminum phenoxide catalyst and heating the mixture to 100°-350°C., preferably in a closed system and in the presence of olefin corresponding in structure to the ortho-alpha-branched alkyl group.