18168-40-6

Basic information

• Product Name: 2-(2-phenylpropan-2-yl)phenol
• Synonyms: 2-(2-phenylpropan-2-yl)phenol;Phenol,2-(1-Methyl-1-phenylethyl)-
• CAS NO: 18168-40-6
• Molecular Formula: C₁₅H₁₆O
• Molecular Weight: 212.29
• Mol File: 18168-40-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 321°Cat760mmHg
• Flash Point: 151.1°C
• Appearance: /
• Density: 1.055g/cm³
• Vapor Pressure: 0.000163mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: 2-(2-phenylpropan-2-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-phenylpropan-2-yl)phenol(18168-40-6)
• EPA Substance Registry System: 2-(2-phenylpropan-2-yl)phenol(18168-40-6)

Safety Data

• Hazardous Substances Data: 18168-40-6(Hazardous Substances Data)

Usage

Appearance

White, crystalline substance

Molecular weight

178.27 g/mol

Function

Potent intravenous sedative-hypnotic agent

Used for

General anesthesia and sedation in medical procedures

Mechanism of action

Enhances the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to sedative and anesthetic effects

Administration

Intravenous

Onset of action

Rapid

Duration of action

Short

Side effects

Respiratory depression, hypotension, and potential for abuse

Clinical use

Widely used for its rapid and reliable sedative and hypnotic effects, despite drawbacks.

InChI:InChI=1/C15H16O/c1-15(2,12-8-4-3-5-9-12)13-10-6-7-11-14(13)16/h3-11,16H,1-2H3

Upstream product

• 98-83-9 isopropenylbenzene 
• 108-95-2 phenol 
• 617-94-7 1-methyl-1-phenylethyl alcohol 

Downstream Products

• 1009103-96-1 2-(2-phenylprop-2-yl)-4-tritylphenol 
• 1582788-13-3 bis[4-bromo-2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)phenoxy]titanium(IV) dichloride 
• 1582788-12-2 bis[2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)-4-chlorophenoxy]titanium(IV) dichloride 
• 1421313-43-0 bis[2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)phenoxy]titanium(IV) dichloride 
• 1582788-00-8 4-bromo-2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)phenol 
• 1582787-99-2 2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)-4-chlorophenol 
• 1582787-95-8 2-{[4-(pent-4-enyloxy)phenylimino]methyl}-6-(2-phenylpropan-2-yl)phenol 
• 1582787-87-8 5-bromo-2-hydroxy-3-(2-phenylpropan-2-yl)benzaldehyde 
• 861903-33-5 2-hydroxy-3-(2-phenylpropan-2-yl)-5-chlorobenzaldehyde 
• 101153-03-1 Cumylphenyl Phosphite 
• 165450-61-3 2-hydroxy-3-(1-methyl-1-phenylethyl)benzaldehyde 

Relevant articles and documents

Synthesis of salicylaldehydes bearing bulky substituents in the positions 3 and 5

Reaction of 2,4-disubstituted phenols with paraformaldehyde in the presence of SnCl4 and 2,6-lutidine afforded a number of new salicylaldehydes, containing bulky substituents (tert-butyl, 1-phenylethyl, 1-(4-tert- butylphenyl)ethyl, α-cumyl, and trityl) in the positions 3 and 5.

Process for preparing para-cumylphenol

A process for preparing p-cumylphenol which comprises reacting phenol and α-methylstyrene in the presence of an inorganic solid acid catalyst having an acid point of an acid strength Ho of up to -3, for example activated clay, and recovering the aimed p--cumylphenol from the reaction mixture thus obtained by distilling the same while introducing an inert gas such as nitrogen and/or steam into the distillation system is disclosed. The p-cumylphenol thus obtained has a high purity and an improved color compared with those obtained by conventional methods.

Phenol transalkylation process

Phenols having an unsubstituted ortho position are transalkylated in the ortho position by mixing them with an ortho-alpha-branched alkylphenol (e.g., 2,6-di-sec-butylphenol) and an aluminum phenoxide catalyst and heating the mixture to 100°-350°C., preferably in a closed system and in the presence of olefin corresponding in structure to the ortho-alpha-branched alkyl group.