181697-05-2

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 185345-56-6 4-(2-oxo-2-phenylethyl)benzenesulfonyl chloride 
• 22958-64-1 4-(carboxy-methyl)-benzene-sulfonamide 
• 395682-94-7 4-aminosulfonylphenylacetyl chloride 
• 71-43-2 benzene 

Downstream Products

• 181696-05-9 [4-[4-(aminosulfonyl)phenyl]-3-phenylisoxazol-5-yl]-3-methylbutan-1-oic acid 
• 181696-07-1 [4-[4-(aminosulfonyl)phenyl]-3-phenylisoxazol-5-yl]butanoic acid 
• 181696-06-0 [[4-[4-(aminosulfonyl)phenyl]-3-phenylisoxazol-5-yl]-methyloxy]acetic acid 
• 181697-14-3 [4-[4-(aminosulfonyl)phenyl]-3-phenyl-isoxazol-5-yl]carboxamide 
• 181696-08-2 4-[5-cyano-3-phenylisoxazol-4-yl]benzenesulfonamide 
• 181697-10-9 [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]butan-1-oic acid 
• 181697-08-5 [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-3-methylbutan-1-oic acid 
• 181697-09-6 [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]-methyloxyacetic acid 
• 181697-13-2 [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxamide 
• 181697-11-0 [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylic acid 
• 181697-12-1 methyl [4-[4-[N-[2,5-dimethylpyrrol]sulfonyl]phenyl]-3-phenylisoxazol-5-yl]carboxylate 
• 181697-07-4 2-[4-[N-[2,5-dimethylpyrrol]-sulfonyl]phenyl]-1-phenyl-ethan-1-one oxime 
• 198470-84-7 parecoxib 

Relevant academic research and scientific papers

Method for preparing Parecoxib

The invention relates to a method for preparing Parecoxib, and belongs to the synthesis field of pharmaceutical chemistry. 1,2-diphenyl-ethanone is used as an starting raw material, a reaction is carried out between the starting raw material and chlorosul

METHOD FOR THE PREPARATION OF DIARYLISOXAZOLE SULFONAMIDE COMPOUNDS AND INTERMEDIATES

The disclosure provides a method for the preparation of a diarylisoxazolé sulfonamide compound comprising contacting a deoxybenzoin with a secondary amine to form a diarylenamine compound; contacting the diarylenamine compound with an acetylating agent to form an acetyl diarylenamine compound; contacting the acetyl diarylenamine compound with a source of hydroxylamine to form an diaryl isoxazolol compound; eliminating water from the diaryl isoxazolol compound to form a diaryl isoxazole compound, chlorosulfonating the diarylisoxazole compound to form a chlorosulfonyl diaryl isoxazole compound; and contacting the chlorosulfonyl diaryl isoxazole compound with a source of ammonia to form the diarylisoxazole sulfonamide compound.

Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof

The present invention relates to sulfonyl-containing 2,3-diarylindole, especially to new compounds of general Formula, to a preparation method for their preparation, to pharmaceutical compositions containing said compound, and to the medical use thereof in the treatment of diseases relating to the inhibition of cyclooxygenase-2 (COX-2).

Discovery of 2-phenyl-3-sulfonylphenyl-indole derivatives as a new class of selective COX-2 inhibitors

2-Sulfonylphenyl-3-phenyl-indole derivatives have been reported to be highly potent and selective COX-2 inhibitors previously. In this paper, the regio-isomeric analogues-2-phenyl-3-sulfonylphenyl-indoles were identified as potent and selective COX-2 inhi

Substituted imidazo 1,2a}azines as selective inhibitors of cox-2

The invention refers to new compounds of formula (I), wherein A and B are selected from the group consisting of N and CH, with the condition that when A is N, B is N; R1is selected from the group consisting of CH3and NH2;

Substituted isoxazoles for the treatment of inflammation

A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula (III) wherein R7 is selected from hydroxyl, lower alkyl, carboxyl, halo, lower carboxylalkyl, lower alkoxycarbonylalkyl, lower alkoxyalkyl, lower carboxyalkoxyalkyl, lower haloalkyl, lower haloalkylsulfonyloxy, lower hydroxyalkyl, lower aryl (hydroxylalkyl), lower carboxyaryloxyalkyl, lower alkoxycarbonylaryloxyalkyl, lower cycloalkyl, lower cycloalkylalkyl, and lower aralkyl; and wherein R8 is one or more radicals independently selected from hydrido, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, lower arylamino, lower aminoalkyl, nitro, halo, lower alkoxy, aminosulfonyl, and lower alkylthio; or a pharmaceutically-acceptable salt thereof.

SUBSTITUTED IMIDAZO 1,2A]AZINES AS SELECTIVE INHIBOTORS OF COX-2

The invention refers to new compounds of formula (I), wherein A and B are selected from the group consisting of N and CH, with the condition that when A is N, B is N; R1 is selected from the group consisting of CH3 and NH2; R2 and R3 are selected from the group consisting of H, CH3, Br, Cl, COCH3 and OCH3; and R4, R5 and R6, are selected from the group consisting of H, F, Cl, Br, (C1-C3)-alkyl, trifluoromethyl, (C1-C3)-alkoxy and trifluoromethoxy. Compounds of formula (I) are prepared by reaction of a substituted aminoazine with a substituted 2-bromo-2-(4-R1-sulfonylphenyl)-1-phenylethanone in a polar solvent. These new compounds inhibit COX-2 with high selectivity over COX-1. They are useful for the treatment of inflamation and/or cyclooxygenase-mediated diseases, having the additional advantage of a reduced potencial for ulcerogenic effects.

Isoxazole compounds as cyclooxygenase inhibitors

A class of substituted isoxazolyl compounds is described for use in treating cyclooxygenase-2 related disorders. Compounds of particular interest are defined by Formula I STR1 wherein R1, R2, and R3, are described in the specification.