1817-51-2

Basic information

• Product Name: 1-PHENYL-1-HEXYN-3-OL
• Synonyms: 1-Phenyl-1-hexin-3-ol;1-Hexyn-3-ol, 1-phenyl-
• CAS NO: 1817-51-2
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.24
• Product Categories: Alkynes;Internal;Organic Building Blocks
• Mol File: 1817-51-2.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 283.6°Cat760mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 0.949 g/mL at 25 °C
• Vapor Pressure: 0.00148mmHg at 25°C
• Refractive Index: n20/D 1.549
• CAS DataBase Reference: 1-PHENYL-1-HEXYN-3-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-1-HEXYN-3-OL(1817-51-2)
• EPA Substance Registry System: 1-PHENYL-1-HEXYN-3-OL(1817-51-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1817-51-2(Hazardous Substances Data)

Usage

General Description

1-PHENYL-1-HEXYN-3-OL is a chemical compound that belongs to the class of phenylalkynes. It is also known as 1-Phenylhex-1-yn-3-ol and has a molecular formula of C12H14O. This chemical is a colorless to pale yellow liquid with a faint odor and is insoluble in water. It is primarily used in the synthesis of various pharmaceuticals, flavors, and fragrances. Additionally, it is also used as a chemical intermediate in organic synthesis and as a reagent in chemical reactions. However, 1-PHENYL-1-HEXYN-3-OL may pose potential health hazards if not handled properly, and caution should be exercised when using this compound.

InChI:InChI=1/C12H14O/c1-2-6-12(13)10-9-11-7-4-3-5-8-11/h3-5,7-8,12-13H,2,6H2,1H3

Upstream product

• 351-78-0 β-fluorostyrene 
• 123-72-8 butyraldehyde 
• 4440-01-1 lithium phenylacetylide 
• 1004-22-4 (phenylethynyl)sodium 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 34252-39-6 3-Hydroperoxy-1-phenyl-1-hexin 
• 536-74-3 phenylacetylene 
• 2579-22-8 Phenylpropargyl aldehyde 
• 10557-57-0 propylmagnesium iodide 
• 1129-65-3 (hex-1-yn-1-yl)benzene 
• 932-88-7 1-iodo-2-phenylethyne 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 71-36-3 butan-1-ol 
• 6738-06-3 phenylethynylmagnesium bromide 

Downstream Products

• 123-72-8 butyraldehyde 
• 536-74-3 phenylacetylene 
• 1214890-85-3 1-(1-phenylhex-1-yn-3-yl)naphthalen-2-ol 
• 1314111-20-0 2,3-diphenylocta-1,3,4-triene 
• 75918-73-9 (4-Benzyl-5-propyl-oxazol-2-yl)-methyl-phenyl-amine 
• 308274-27-3 3-Azidocarbonyloxy-1-phenyl-1-hexyne 
• 82297-62-9 (E)-1-phenylhex-1-en-3-one 
• 75918-66-0 1-Methyl-1-phenyl-2-(1-phenylethynyl-butyl)-isourea 
• 73267-71-7 1-phenyl-1-hexyn-3-yl 1-pyrrolidinecarboximidate 
• 27975-82-2 (3-bromohex-1-yn-1-yl)benzene 
• 14252-32-5 1-phenyl-hex-1-yn-3-one 
• 134240-74-7 1-n-propyl-3-phenylprop-2-ynyl acetate 
• 79159-59-4 (E)-1-phenyl-1-yn-hex-3-ene 
• 93-58-3 benzoic acid methyl ester 

Relevant articles and documents

Hydrogen-Bond-Promoted Friedel-Crafts Reaction of Secondary Propargylic Fluorides: Preparation of 1-Alkyl-1-aryl-2-alkynes

We report that aromatic propargylation is achievable with secondary propargylic fluorides, thus affording 1-alkyl-1-aryl-2-alkynes. In the present case, hydrogen bonding is responsible for the activation of the C-F bond. A large excess of arene nucleophil

Benzene-1,3,5-triyl Triformate (TFBen)-Promoted Palladium-Catalyzed Carbonylative Synthesis of 2-Oxo-2,5-dihydropyrroles from Propargyl Amines

In this letter, we developed a palladium-catalyzed procedure for the cyclocarbonylation of propargyl amines. Benzene-1,3,5-triyl triformate (TFBen) has been explored as the CO source and also as the key promotor. Various substituted 2-oxo-dihydropyrroles were produced in a facile manner in good yields (up to 90%).

Nickel-Catalyzed Asymmetric Friedel-Crafts Propargylation of 3-Substituted Indoles with Propargylic Carbonates Bearing an Internal Alkyne Group

The nickel-catalyzed highly enantioselective Friedel-Crafts propargylation of 3-substituted indoles with propargylic carbonates bearing an internal alkyne group was developed. A wide array of the propargylic carbonates as well as 3-substituted indoles can be applicable to the asymmetric nickel catalysis, providing the corresponding chiral C-3 propargylated indolenine derivatives bearing two vicinal chiral centers in up to 89% yield with up to >99% ee and 94:6 dr (24 examples).