181708-57-6

Basic information

• Product Name: 3-(2-Iodo-benzyl)-5-trimethylsilanyl-pent-4-yn-1-ol
• Synonyms: 3-(2-Iodo-benzyl)-5-trimethylsilanyl-pent-4-yn-1-ol
• CAS NO: 181708-57-6
• Molecular Weight: 372.321
• Mol File: 181708-57-6.mol

Chemical Properties

• CAS DataBase Reference: 3-(2-Iodo-benzyl)-5-trimethylsilanyl-pent-4-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Iodo-benzyl)-5-trimethylsilanyl-pent-4-yn-1-ol(181708-57-6)
• EPA Substance Registry System: 3-(2-Iodo-benzyl)-5-trimethylsilanyl-pent-4-yn-1-ol(181708-57-6)

Safety Data

• Hazardous Substances Data: 181708-57-6(Hazardous Substances Data)

Upstream product

• 13224-84-5 5-trimethylsilanyl-pent-4-yn-1-ol 
• 40400-13-3 2-Iodobenzyl bromide 

Downstream Products

• 175235-49-1 3-(2-iodobenzyl)-4-pentynoic acid 
• 175235-55-9 3-(2-Iodo-benzyl)-pent-4-yn-1-ol 

Relevant articles and documents

Palladium-mediated intramolecular cyclization of substituted pentynoic acids. A new route to γ-arylidenebutyrolactones

Benzo-annulated enol lactones are obtained in good yields from pentynoic acids 3- or 5- substituted with an iodo-aryl moiety by palladium-catalyzed cyclization of their potassium carboxylates.

A new route to γ-arylidenebutyrolactones via a tandem carbopalladation-heterocyclisation sequence: A formal synthesis of U-68,215

Benzo-annulated enol lactones are obtained in good yields from pentynoic acids 3- or 5-substituted with an iodo-aryl moiety by palladium-catalyzed cyclization of their potassium carboxylates. Using this approach, an efficient new route to U-68,215 is described.