181708-61-2Relevant academic research and scientific papers
Intramolecular Pd-Catalyzed Formal anti-Carboalkoxylation of Alkynes: Access to Tetrasubstituted Enol Ethers
Schitter, Theresa,Jones, Peter G.,Werz, Daniel B.
, p. 13446 - 13449 (2018)
An intramolecular Pd-catalyzed formal anti-carboalkoxylation reaction is presented that provides access to tetrasubstituted enol ethers. The key to success is a cascade consisting of a formal anti-carbopalladation of a carbon–carbon triple bond followed by a nucleophilic attack of a hydroxy group at the emerging vinyl organopalladium species. The desired transformation proceeded smoothly with primary, secondary, and tertiary alcohols, and even with phenols. Depending on the substitution pattern of the enol ethers, a further Tsuji–Trost-type step may occur resulting in oligocyclic ketals.
A new route to γ-arylidenebutyrolactones via a tandem carbopalladation-heterocyclisation sequence: A formal synthesis of U-68,215
Cavicchioli, Marcello,Decortiat, Sylvie,Bouyssi, Didier,Gore, Jacques,Balme, Genevieve
, p. 11463 - 11478 (2007/10/03)
Benzo-annulated enol lactones are obtained in good yields from pentynoic acids 3- or 5-substituted with an iodo-aryl moiety by palladium-catalyzed cyclization of their potassium carboxylates. Using this approach, an efficient new route to U-68,215 is described.
