181711-37-5

Upstream product

• 66-22-8 uracil 
• 109428-30-0 1,5:2,3-anhydro-4,6-O-benzylidene-D-allitol 

Downstream Products

• 181711-38-6 methanesulfonic acid (4aR,7R,8S,8aR)-7-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 181961-68-2 1-((4aR,7R,8R,8aS)-8-hydroxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl)-1H-pyrimidine-2,4-dione 
• 181711-39-7 Acetic acid (4aR,7R,8R,8aS)-7-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 
• 215959-66-3 1,5-anhydro-3-O-benzoyl-6-O-monomethoxytrityl-2-deoxy-2-(uracil-1-yl)-D-altro-hexitol 
• 215959-65-2 1,5-anhydro-3-O-benzoyl-2-deoxy-2-(uracil-1-yl)-D-altro-hexitol 

Relevant academic research and scientific papers

Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety

Nucleoside analogues containing a 2-deoxy-1,5-anhydro-D-mannitol and a pyrimidine base moiety were synthesized starting from D-glucose via a nucleophilic opening of an epoxide with the heterocyclic base and an inversion of configuration at the 3'-position. Study of the conformation of these molecules, that show some activity against herpesviruses (HSV, VZV, CMV) should increase our understanding of the structural requirements of hexitol nucleosides for antiviral activity.

METHOD OF PREPARATION OF NOVEL NUCLEOSIDE ANALOGS AND USES

Processes for the preparation of racemic and optically active nucleoside analogs of formula (A) are described. These compounds are useful as anti-infective agents, antisense therapeutic agents and hybridization assay probes.

1,5-Anhydro-2-deoxy-D-altritol oligonucleotides as conformationally restricted analogues of RNA

As part of a project concerning the investigation of new hexitol nucleic acids (HNA), the 1,5-anhydro-2-deoxy-D-altritol nucleoside building blocks with a uracil, cytosine, adenine and guanine base moiety were synthesized. The uracil analogue was used for the automated synthesis of corresponding oligonucleotides. Hybridization capabilities of these altritol nucleic acids (ANA) are illustrated by the Tm values obtained for the (d(h)U)13/(dA)13 duplex.