181725-36-0Relevant academic research and scientific papers
Functionalized biodegradable triclosan monomers and oligomers for controlled release
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Page/Page column 51-52, (2011/11/13)
This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.
CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS
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, (2009/04/24)
The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.
FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE
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, (2009/05/29)
This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.
Enantioselective discrimination in the self-assembly of [2]pseudorotaxanes
Asakawa, Masumi,Janssen, Henk M.,Meijer,Pasini, Dario,Stoddart, J. Fraser
, p. 983 - 986 (2007/10/03)
The combination of (i) an optically active, axially chiral π-electron-deficient tetracationic cyclophane derivative of cyclobis(paraquat-p-phenylene), in which both of the p-phenylene spacers have been replaced by axially-chiral 3,3′-disubstituted binaphthol spacers, and (ii) enantiomeric, π-electron-rich substrates, in which a hydroquinone ring is inserted into the polyether backbone terminated by carboxyl groups and substituted in a C2-symmetric manner by two methyl groups, thus creating two equivalent chiral centers in the substrate, produces in solution 1:1 complexes in which the π-electron-rich substrates are inserted into the π-electron-deficient cavities of the cyclophanes in a pseudorotaxane-like manner. The differences in the free energies of complexation for (RR) and (SS) enantiomers of the π-electron-rich substrates span the range from 0.1 to 0.7 kcal mol-1. Chiral recognition becomes more effective the closer the chiral centers are to the hydroquinone templating unit. CD spectroscopy reveals that the different modes of binding of the enantiomeric substrates by the axially chiral tetracationic cyclophane are not accompanied by drastically different core geometries for the [2]pseudorotaxanes. Thus, the chirality of the complex is governed primarily by the properties of the rigid receptor. The combination of the D2 symmetry of the receptor with the C2 symmetry of the substrates has been found to be particularly effective, considering that the chiral centers on the substrates are located on polyether chains which possess a high degree of conformational freedom.
Syntheses of ligands containing two and three 2,2'-(bisamino)diphenyl ether units designed for molecular self-assembly on lithiation
Ashton, Peter R.,H?rner, Bernd,Kocian, Oldrich,Menzer, Stephan,White, Andrew J. P.,Stoddart, J. Fraser,Williams, David J.
, p. 930 - 940 (2007/10/03)
The syntheses of polyamines containing two or three 2,2'-(bisamino)diphenyl ether units linked together, designed for self-assembly following lithiation, are reported. The X-ray crystal structures of two of the bis[2,2'-(bisamido)diphenyl ethers] are described. The ligand, which is linked by an ethylene glycol spacer, exhibits a coiled conformation constrained by intramolecular hydrogen bonds and supplemented by [CH-π] interactions. The ligand, which is linked by a more rigid bridge, containing a paraphenylene unit, displays a stretched conformation stabilised by intramolecular hydrogen bonds and intramolecular T-type aromatic-aromatic edge-to-face interactions.
