181772-16-7 Usage
Uses
Used in Pharmaceutical Industry:
3,5-Bis(trifluoromethyl)hydrocinnamic acid is used as a key intermediate in the synthesis of novel biologically active amides. These amides possess potential therapeutic properties and can be further developed into new drugs for the treatment of various diseases.
Used in Chemical Synthesis:
In the field of organic chemistry, 3,5-bis(trifluoromethyl)hydrocinnamic acid serves as a valuable precursor for the preparation of a wide range of chemical compounds. Its unique structure allows for various synthetic transformations, making it a useful building block in the development of new molecules with specific functions and applications.
Used in Material Science:
The distinctive properties of 3,5-bis(trifluoromethyl)hydrocinnamic acid also make it a promising candidate for the development of new materials with unique characteristics. Its potential applications in material science include the creation of advanced polymers, coatings, and other materials with improved properties, such as enhanced stability, durability, or specific interactions with biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 181772-16-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,7,7 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 181772-16:
(8*1)+(7*8)+(6*1)+(5*7)+(4*7)+(3*2)+(2*1)+(1*6)=147
147 % 10 = 7
So 181772-16-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H8F6O2/c12-10(13,14)7-3-6(1-2-9(18)19)4-8(5-7)11(15,16)17/h3-5H,1-2H2,(H,18,19)
181772-16-7Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists
Li, Fu-Nan,Kim, Nam-Jung,Paek, Seung-Mann,Kwon, Do-Yeon,Min, Kyung Hoon,Jeong, Yeon-Su,Kim, Sun-Young,Park, Young-Ho,Kim, Hee-Doo,Park, Hyeung-Geun,Suh, Young-Ger
experimental part, p. 3557 - 3567 (2009/09/27)
We have developed a new class of diarylalkyl amides as novel TRPV1 antagonists. They exhibited potent 45Ca2+ uptake inhibitions in rat DRG neuron. In particular, the amide 59 was identified as a potent antagonist with IC50 of 57 nM. The synthesis and structure-activity relationship of the diarylalkyl amides are also described.
Direct synthesis of 3-arylpropionic acids by tetraphosphine/palladium catalysed Heck reactions of aryl halides with acrolein ethylene acetal
Lemhadri, Mhamed,Doucet, Henri,Santelli, Maurice
, p. 11533 - 11540 (2007/10/03)
Through the use of [PdCl(C3H5)]2/Cis,cis, cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane as a catalyst, a range of aryl bromides undergoes Heck reaction with acrolein ethylene acetal. With this acetal, the selective formation of 3-arylpropionic acids/esters was observed. The functional group tolerance on the aryl halide is remarkable; substituents such as fluoro, methyl, methoxy, acetyl, formyl, benzoyl, nitro or nitrile are tolerated. Furthermore, this catalyst can be used at low loading, even for reactions of sterically hindered aryl bromides. Graphical Abstract.
