181777-01-5Relevant academic research and scientific papers
Formation of multi-stereogenic centers using a catalytic diastereoselective Henry reaction
Arai, Takayoshi,Taneda, Yoshinori,Endo, Yoko
supporting information; scheme or table, p. 7936 - 7938 (2011/01/04)
A diastereoselective Henry reaction of chiral aldehydes with nitroalkanes was developed using a chiral sulfonyldiamine (L1)-CuCl complex. The reaction of (R)-2-phenylpropanal and nitromethane was smoothly catalyzed by the (S,S,S)-L1-CuCl complex to give the adduct with 99/1 syn/anti selectivity in 99% ee. In the reaction of (S)-2-phenylpropanal and nitroethane, the (R,R,R)-L1-CuCl catalyst yielded the expected three contiguous stereogenic centers in a highly syn-selective Henry reaction.
Method of forming amino acid-derived diaminopropanols useful as chemical intermediates for protease-inhibitors
-
, (2008/06/13)
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method
Amino acid-derived diaminopropanols
-
, (2008/06/13)
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. The method includes contacting a nitromethyl amino acid compound with at least one reducing agent to form the 1,3-diamino-3-substituted-2-propanol chemical intermediate.
Method preparing amino acid-derived diaminopropanols
-
, (2008/06/13)
The present invention relates to a method of forming a 1,3-diamino-3-substituted-2-propanol chemical intermediate from which various chemicals, such as selected protease-inhibitors and other drugs, as well as polymers, can be synthesized. This method
