62084-21-3

Basic information

• Product Name: 3-amino-2-hydroxy-4-phenylbutanoic acid
• Synonyms: 3-amino-2-hydroxy-4-phenylbutanoic acid;Allophenylnorstatine((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid);Apns;Benzenebutanoic acid, b-aMino-a-hydroxy-
• CAS NO: 62084-21-3
• Molecular Formula: C₁₀H₁₃NO₃
• Molecular Weight: 195.22
• Mol File: 62084-21-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-amino-2-hydroxy-4-phenylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-2-hydroxy-4-phenylbutanoic acid(62084-21-3)
• EPA Substance Registry System: 3-amino-2-hydroxy-4-phenylbutanoic acid(62084-21-3)

Safety Data

• Hazardous Substances Data: 62084-21-3(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 103127-53-3 N-tert-butyloxycarbonyl-2-amino-3-phenylpropionaldehyde 
• 73845-40-6 methyl trans-2,3-epoxy-4-phenylbutanoate 
• 63158-17-8 methyl (E)-4-phenyl-2-butenoate 
• 136354-01-3 N-methoxycarbonyl-1-methoxy-2-phenylethylamine 
• 75443-87-7 methyl DL-erythro-3-amino-2-hydroxy-4-phenylbutanoate 
• 6540-96-1 2-benzyl-4-pentenoic acid 
• 501-52-0 3-Phenylpropionic acid 
• 73845-40-6 methyl cis-2,3-epoxy-4-phenylbutanoate 
• 34541-75-8 methyl (Z)-4-phenyl-2-butenoate 
• 75414-66-3 methyl threo-3-hydroxy-2-tosyloxy-4-phenylbutanoate 
• 75414-69-6 methyl threo-2,3-dihydroxy-4-phenylbutanoate 
• 37779-49-0 methyl 3-oxo-4-phenylbutanoate 
• 73845-38-2 methyl 4-phenylbut-2-ynoate 

Downstream Products

• 123206-33-7 N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<2-hydroxy-3-methoxy-3-oxo-1-(phenylmethyl)propyl>-L-prolinamide 
• 123206-34-8 N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-N-<3-methoxy-2,3-dioxo-1-(phenylmethyl)propyl>-L-prolinamide 
• 118943-11-6 3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-2-hydroxy-4-phenyl-butyric acid methyl ester 
• 118943-12-7 3-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-2-oxo-4-phenyl-butyric acid methyl ester 
• 106771-34-0 3-Benzoylamino-2-oxo-4-phenyl-butyric acid methyl ester 
• 73337-88-9 3-Benzoylamino-2-hydroxy-4-phenyl-butyric acid methyl ester 
• 123206-29-1 methyl 3-amino-2-hydroxy-4-phenylbutanoate 

Relevant articles and documents

N -Boc amines to oxazolidinones via Pd(II)/bis-sulfoxide/br?nsted acid Co-catalyzed allylic C-H oxidation

A Pd(II)/bis-sulfoxide/Br?nsted acid catalyzed allylic C-H oxidation reaction for the synthesis of oxazolidinones from simple N-Boc amines is reported. A range of oxazolidinones are furnished in good yields (avg 63%) and excellent diastereoselectivities (avg 15:1) to furnish products regioisomeric from those previously obtained using allylic C-H amination reactions. Mechanistic studies suggest the role of the phosphoric acid is to furnish a Pd(II)bis-sulfoxide phosphate catalyst that promotes allylic C-H cleavage and π-allylPd functionalization with a weak, aprotic oxygen nucleophile and to assist in catalyst regeneration.

PROCESS FOR PRODUCING 3-AMINO-2-HYDROXYPROPIONIC ACID DERIVATIVES

The present invention provides a process for preparing 3-amino-2-hydroxypropionic acid derivatives (1) which does not use dangerous reagents, is economically advantageous, and is suitable for an industrial production, which process comprises:treating N-protected-3-amino-2-hydroxypropionic acid derivatives (2) having a steric configuration at 2-position carbon reverse to that of derivatives (1) with a leaving group-introducing agent to convert into N-protected-3-aminopropionic acid derivatives (3),then treating the derivatives with a basic substance to convert into substituted-3-amino-2-hydroxypropionic acid derivatives (4) having an inverted steric configuration at 2-position carbon,and then converting the derivatives into 3-amino-2-hydroxypropionic acid derivatives (1).

Synthesis of nitroalcohol diastereomers

The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula I: In Structural Formula I, R is an amine protecting group, and R1is an amino acid side-chain, a pr

Process for the production of a β-amino alcohol

A process for producing 2-?3(S)-amino-2-(R)-hydroxyl-4-phenyl butyl!-N-tert,butyl decahydro-(4aS,8aS)-isoquinoline-e(S)-carboxamide of the formula (I) via 3(S)-?lower alkoxy carbonyl amino, phenoxy carbonyl amino or benzyl oxycarbonyl amino!-2-hydroxy-4-phenyl butyric acid and process for producing said acid.

Diastereoselective Synthesis of 3-Amino-2-Hydroxyalkanoic Acid Derivatives

Both diastereomers of 3-amino-2-hydroxyalkanoic acid derivatives were synthesized selectively by LDA-induced reaction of N-methoxycarbonyl-1-methoxyamines with O-protected N,N-dimethylglycolamides.The inversion of the diastereoselectivity was highly achieved by 1) selecting the O-protecting groups and 2) the addition of Ti(OPr-i)4.

Novel spergualin-related compounds and compositions

The present invention relates to novel spergualin-related compounds represented by the general formula [I]: STR1 wherein X is --(CH2)1?5 or STR2 Y is a hydrogen atom or a residue obtained by removing a hydroxyl group from the carboxyl group of an amino acid or a peptide; m is 0, 1 or 2 and n is 1 or 2, with the proviso that Y is not a hydrogen atom when n is 2 and m is 0. This compounds are stable and exhibit a high immunosuppressive activity.

Synthesis of peptidyl fluoromethyl ketones and peptidyl α-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G

Comparison of MeO-Suc-Val-Pro-Phe-CO2Me (29) and MeO-Suc-Ala-Ala-Pro-Phe-CO2Me (25) with their corresponding trifluoromethyl ketones 9a and 9b, respectively, in rat and human neutrophil cathepsin G assays showed the α-keto esters to

OXIDATION OF α-HYDROXY ESTERS TO α-KETO ESTERS USING THE DESS-MARTIN PERIODINANE REAGENT

The oxidation of α-hydroxy esters, including peptidyl α-hydroxy esters, with the Dess-Martin periodinane reagent is a useful and general method for the preparation of α-keto esters.

INTERMEDIATES IN POLYPEPTIDE SYNTHESIS

Bis(t-butoxycarbonyl) derivatives of phenylalanylhistidine as intermediates in the synthesis of rennin inhibiting polypeptides.