181785-91-1Relevant articles and documents
2′-fluoronucleosides
-
Page/Page column 52, (2015/11/30)
2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base;R1 is OH, H, OR3, N3, CN, halogen, CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy;R2 is H, phosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving benzyl, a lipid, an amino acid, peptide, or cholesterol; andR3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group; or a pharmaceutically acceptable salt thereof.
Synthesis and anti-HIV and anti-HBV activities of 2'-fluoro-2',3'- unsaturated L-nucleosides
Lee, Kyeong,Choi, Yongseok,Gullen, Elizabeth,Schlueter-Wirtz, Susan,Schinazi, Raymond F.,Cheng, Yung-Chi,Chu, Chung K.
, p. 1320 - 1328 (2007/10/03)
The synthesis of L-nucleoside analogues containing 2'-vinylic fluoride was accomplished by direct condensation method, and their anti-HIV and anti- HBV activities were evaluated in vitro. The key intermediate 8, the sugar moiety of our target compounds, w
