181787-30-4

Upstream product

• 64325-78-6 N₆-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 142182-95-4 P/S_P>-5'-O-(4,4'-dimethoxytrityl)thymidine-3'-O-(N,N-diisopropylamino,n-octyl)-phosphine 
• 93134-36-2 5'-O-(4,4'-dimethoxytrityl)-N⁶-benzoyl-3'-O-levulinoyl-2'-deoxyadenosine 
• 85231-45-4 N-benzoyl-3'-O-levulinoyl-2'-deoxy-β-D-adenosine 

Relevant academic research and scientific papers

Synthesis and duplex stability of oligodeoxynucleotides containing stereoregular or stereorandom octylphosphonate linkages

The synthesis of oligodeoxynucleotide pentadecamers containing two octylphosphonate linkages [3'-O-P(=O)(n-C8H17)-O-5'] with stereoregular or stereorandom chirality is described. The introduction of random octylphosphonate linkages was performed using a monomeric nucleoside octylphosphonamidite as synthon whereas the introduction of stereoregular linkages could be accomplished by the use of stereoregular dimers containing a preformed octylphosphonate linkage. The novel oligodeoxynucleotides were characterized by electrospray ionization mass spectrometry and the influence of chirality of the modified linkages on the duplex stability was studied. Furthermore, end-capped oligodeoxynucleotides having two octylphosphonate linkages at either end which were directed against HSV-1 mRNA have been synthesized for investigation as antisense drugs.