181803-05-4

Basic information

• Product Name: ethyl (4E)-8-benzyloxy-4-enoctanoate
• Synonyms: ethyl (4E)-8-benzyloxy-4-enoctanoate
• CAS NO: 181803-05-4
• Molecular Weight: 276.376
• Mol File: 181803-05-4.mol

Chemical Properties

• CAS DataBase Reference: ethyl (4E)-8-benzyloxy-4-enoctanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (4E)-8-benzyloxy-4-enoctanoate(181803-05-4)
• EPA Substance Registry System: ethyl (4E)-8-benzyloxy-4-enoctanoate(181803-05-4)

Safety Data

• Hazardous Substances Data: 181803-05-4(Hazardous Substances Data)

Upstream product

• 126260-80-8 (3RS)-6-benzyloxyhex-1-en-3-ol 
• 78-39-7 Triethyl orthoacetate 
• 5470-84-8 4-benzyloxybutanal 

Downstream Products

• 1054649-80-7 (4S,5S)-8-Benzyloxy-4,5-dihydroxy-octanoic acid ethyl ester 
• 198411-03-9 (E)-8-(benzyloxy)oct-4-en-1-ol 
• 862558-02-9 ((E)-8-Iodo-oct-4-enyloxymethyl)-benzene 
• 862557-01-5 (S)-5-((4Z,8E)-(R)-12-Benzyloxy-1-hydroxy-dodeca-4,8-dienyl)-dihydro-furan-2-one 
• 862557-07-1 (S)-5-((4Z,8E)-(S)-12-Benzyloxy-1-hydroxy-dodeca-4,8-dienyl)-dihydro-furan-2-one 
• 862556-98-7 (R)-5-((4Z,8E)-(R)-12-Benzyloxy-1-hydroxy-dodeca-4,8-dienyl)-dihydro-furan-2-one 
• 862557-04-8 (R)-5-((4Z,8E)-(S)-12-Benzyloxy-1-hydroxy-dodeca-4,8-dienyl)-dihydro-furan-2-one 
• 862557-27-5 (2S,2'S,5'S)-5'-((E)-(R)-8-Benzyloxy-1-hydroxy-oct-4-enyl)-tetrahydro-[2,2']bifuranyl-5-one 
• 862557-25-3 (2R,2'S,5'S)-5'-((E)-(R)-8-Benzyloxy-1-hydroxy-oct-4-enyl)-tetrahydro-[2,2']bifuranyl-5-one 
• 862557-22-0 (2R,2'R,5'R)-5'-((E)-(S)-8-Benzyloxy-1-hydroxy-oct-4-enyl)-tetrahydro-[2,2']bifuranyl-5-one 
• 862556-20-5 (2R,2'S,5'S,2''R,5''R)-5''-((S)-4-Benzyloxy-1-hydroxy-butyl)-hexahydro-[2,2';5',2'']terfuran-5-one 
• 862556-32-9 (2S,2'R,5'R,2''S,5''S)-5''-((S)-4-Benzyloxy-1-hydroxy-butyl)-hexahydro-[2,2';5',2'']terfuran-5-one 
• 862556-15-8 (2R,2'R,5'R,2''S,5''S)-5''-((S)-4-Benzyloxy-1-hydroxy-butyl)-hexahydro-[2,2';5',2'']terfuran-5-one 
• 862555-58-6 (2R,2'R,5'R,2''R,5''R)-5''-((R)-4-Benzyloxy-1-hydroxy-butyl)-hexahydro-[2,2';5',2'']terfuran-5-one 

Relevant articles and documents

Total synthesis of bongkrekic acid via sequential suzuki-miyaura coupling reactions

An efficient total synthesis of (+)-bongkrekic acid, a potent apoptosis inhibitor, has been accomplished by employing a convergent strategy based on the Suzuki-Miyaura coupling of three fully functionalized segments. Georg Thieme Verlag Stuttgart.

Total Synthesis of Asimicin and Bullatacin

The efficient total synthesis of asimicin, 1, and bullatacin, 2, has demonstrated the advantages of three different strategies for the synthesis of the tricyclic intermediates 6 and 7, which represent the key fragment of the bis-THF Annonaceous acetogenins. The naked carbon skeleton strategy is based on the production of all asymmetric centers by selective placement of the oxygen functions onto an unsaturated, nonfunctionalized carbon skeleton. Diversity in this approach arises from the relative timing of highly stereoselective reactions, such as the Sharpless asymmetric dihydroxylation (AD) reaction, the Kennedy oxidative cyclization (OC) with rhenium(VII) oxide, the Mitsunobu-type alcohol epimerization reaction, and the Williamson etherification reaction. The convergent strategy, which is based on the combinatorial coupling of two series of diastereomeric fragments, to produce intermediates such as 11 and 12, enjoys the advantages of both efficiency and versatility. The third approach, which is based on partially functionalized intermediates, such as 13, combines the advantages of both the linear and the convergent strategies-synthetic efficiency and diversity.