Welcome to LookChem.com Sign In|Join Free

CAS

  • or

18181-93-6

Post Buying Request

18181-93-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

18181-93-6 Usage

Description

2,4-Diamino-6,7-diphenyl-pteridine is a heterocyclic chemical compound belonging to the class of pteridine derivatives. It features a pteridine core with two amino groups and two phenyl groups attached, endowing it with a unique structure that makes it a versatile compound for various applications in medicine, chemistry, and biotechnology.

Uses

Used in Pharmaceutical Synthesis:
2,4-Diamino-6,7-diphenyl-pteridine is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Dye Production:
2,4-Diamino-6,7-diphenyl-pteridine is also utilized in the production of dyes due to its chemical properties, contributing to the coloration of various materials.
Used in Biological Research:
2,4-Diamino-6,7-diphenyl-pteridine is used as a fluorescent probe in biological and chemical applications. Its fluorescent properties make it suitable for tracking and visualizing biological processes at the molecular level.
Used in Anticancer Research:
In the field of oncology, 2,4-Diamino-6,7-diphenyl-pteridine is studied for its potential anti-cancer properties. It is being investigated for its ability to target and inhibit the growth of cancer cells, offering a promising avenue for the development of novel cancer therapies.
Used in Antiviral Applications:
2,4-Diamino-6,7-diphenyl-pteridine is explored for its potential anti-viral activities, suggesting that it could be used in the development of treatments for viral infections by interfering with viral replication or assembly processes.
Used in Anti-inflammatory Research:
2,4-Diamino-6,7-diphenyl-pteridine is also being studied for its potential anti-inflammatory properties, which could lead to its use in the treatment of inflammatory diseases by modulating the immune response and reducing inflammation.

Check Digit Verification of cas no

The CAS Registry Mumber 18181-93-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,1,8 and 1 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 18181-93:
(7*1)+(6*8)+(5*1)+(4*8)+(3*1)+(2*9)+(1*3)=116
116 % 10 = 6
So 18181-93-6 is a valid CAS Registry Number.
InChI:InChI=1/C18H14N6/c19-16-15-17(24-18(20)23-16)22-14(12-9-5-2-6-10-12)13(21-15)11-7-3-1-4-8-11/h1-10H,(H4,19,20,22,23,24)

18181-93-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 6,7-diphenylpteridine-2,4-diamine

1.2 Other means of identification

Product number -
Other names 2,4-Diamino-6,7-diphenylpteridine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18181-93-6 SDS

18181-93-6Relevant articles and documents

Designing Dihydrofolate Reductase Inhibitors as X-ray Radiosensitizers to Reverse Radioresistance of Cervical Cancer

Liang, Yuanwei,Zeng, Delong,You, Yuanyuan,Ma, Bin,Li, Xiaoling,Chen, Tianfeng

, p. 1421 - 1428 (2020)

X-ray radiotherapy has been widely used in the treatment of cervical cancer, a common gynecologic malignant tumor. However, the therapeutic efficacy tends to be indistinctive. One major reason for this is amplification of the dihydrofolate reductase (DHFR) gene, which causes an increase in DHFR activity and attenuation of the treatment effect. To solve this problem, we synthesized a series of DHFR inhibitors derived from methotrexate (MTX) analogues as radiotherapy sensitizers. Activity screening revealed that compound 2a exerted the best inhibitory effect toward DHFR activity. In combination with X-ray radiotherapy (4 Gy), 2a showed much more prominent antiproliferative activity on cervical cancer cells than 2a or X-rays alone and revealed higher selectivity and radiosensitization than MTX. In vitro experiments showed that 2a + X-rays significantly induced cell apoptosis, as revealed by the increase in the Sub-G1 population and activation of caspase 3, 8, and 9. The in vivo antitumor effect demonstrated that in the presence of X-rays, 2a effectively suppressed tumor growth and did not cause obvious side effects. In conclusion, as a DHFR inhibitor, 2a successfully reversed the radioresistance problem induced by radiotherapy and greatly promoted the therapeutic effect. This is a promising candidate for tumor treatment that deserves further research and development. This study clearly demonstrates that DHFR inhibitors could be developed as promising radiosensitizers in the treatment of cervical cancer and that further research to improve their activity and potential in future clinical use is deserved.

PROTECTION AND DEPROTECTION OF FUSED 2-AMINO-4(3H)PYRIMIDONES: CONVERSION OF PTERINS AND 5-DEAZAPTERINS TO 2,4-DIAMINO DERIVATIVES

Taylor, Edward C.,Otiv, S. R.,Durucasu, Inci

, p. 1883 - 1895 (2007/10/02)

5-Deazapterins and pterins are readily converted to their 4-deoxy-4-amino derivatives (a lactam-to-amidine conversion) by reaction with 4-chlorophenyl phosphorodichloridate and 1,2,4-triazole to give intermediate 4- derivatives, followed by reaction with aqueous ammonia.Some anomalous results obtained by application of the Mitsunobu reaction (normally a lactam-to-lactim ether conversion) to 5-deazapterins are detailed.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 18181-93-6