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181823-86-9

2-[(2,4-dimethoxybenzyl)thio]-6-methylpyridine-3-carboxylic acid is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 181823-86-9 Structure

  • Basic information

    1. Product Name: 2-[(2,4-dimethoxybenzyl)thio]-6-methylpyridine-3-carboxylic acid
    2. Synonyms: 2-[(2,4-dimethoxybenzyl)thio]-6-methylpyridine-3-carboxylic acid
    3. CAS NO:181823-86-9
    4. Molecular Formula:
    5. Molecular Weight: 319.381
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 181823-86-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-[(2,4-dimethoxybenzyl)thio]-6-methylpyridine-3-carboxylic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-[(2,4-dimethoxybenzyl)thio]-6-methylpyridine-3-carboxylic acid(181823-86-9)
    11. EPA Substance Registry System: 2-[(2,4-dimethoxybenzyl)thio]-6-methylpyridine-3-carboxylic acid(181823-86-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 181823-86-9(Hazardous Substances Data)

181823-86-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 181823-86-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,1,8,2 and 3 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 181823-86:
(8*1)+(7*8)+(6*1)+(5*8)+(4*2)+(3*3)+(2*8)+(1*6)=149
149 % 10 = 9
So 181823-86-9 is a valid CAS Registry Number.

181823-86-9Relevant articles and documents

Nicotinamide derivatives as a new class of gastric (H+/K+)-ATPase inhibitors. II. Synthesis and structure-activity relationships of 2-[(2,4- dimethoxyhenzyl)sulfinyl]-N-(4-pyridinyl)pyridine-3-carboxamides

Terauchi, Hideo,Tanitame, Akihiko,Tada, Keiko,Nakamura, Keiji,Seto, Yasuhiro,Nishikawa, Yoshinori

, p. 1027 - 1038 (1997)

Members of a new series of 2-[(2,4-dimethoxybenzyl)sulfinyl]-N-(4- pyridinyl)pyridine-3-carboxamides were synthesized and evaluated for their gastric antisecretory activity and the ability to inhibit cytochrome P450- dependent O-dealkylation of 7-ethoxycoumarin (7-EC) in rat liver microsomes. Several of the compounds synthesized exhibited potent inhibitory activities against both [14C]aminopyrine accumulation stimulated by dibutyryl cyclic AMP in isolated rabbit parietal cells and histamine-induced gastric acid secretion in pylorus-ligated rats when administered intraduodenally; their inhibitory activities were equivalent to or superior to those of the parent compound [2[(2,4-dimethoxybenzyl)sulfinyl]-N-(4-pyridinyl)pyridine-3- carboxamide] and omeprazole. Among the compounds having potent antisecretory activity in vitro and in vivo, 2-[(2,4-dimethoxybenzyl)sulfinyl]-N-(2,5- dimethyl-4-pyridinyl)pyridine-3-carboxamide and 2-[(2,4- dimethoxybenzyl)sulfinyl]-N-(2,6-dimethyl-4-pyridinyl)pyridine-3-carboxamide in particular showed lower inhibitory activity against the 7-EC deethylase than omeprazole. It seems probable that, unlike omeprazole, these compounds do not interact with a metabolism of other drugs in vivo. These compounds, therefore, are considered to be more promising candidate agents for treating acid-related gastrointestinal disorders than the parent compound reported previously.

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