181863-84-3Relevant academic research and scientific papers
Heterocyclic amides: Inhibitors of acyl-CoA:cholesterol O-acyl transferase with hypocholesterolemic activity in several species and antiatherosclerotic activity in the rabbit
White, Andrew D.,Purchase II, Claude F.,Picard, Joseph A.,Anderson, Maureen K.,Mueller, Sandra Bak,Bocan, Thomas M. A.,Bousley, Richard F.,Hamelehle, Katherine L.,Krause, Brian R.,Lee, Peter,Stanfield, Richard L.,Reindel, James F.
, p. 3908 - 3919 (2007/10/03)
A series of heterocyclic amides were synthesized and evaluated as inhibitors of acyl-CoA: cholesterol O-acyltransferase (ACAT) in vitro and for cholesterol lowering in cholesterol-fed rats. Compounds were evaluated for cell-based macrophage ACAT inhibitio
