181868-10-0Relevant academic research and scientific papers
Synthesis and characterization of new diisocyanide rhenium complexes. Comparison with the homoleptic 99mTc complex
Bouquillon,Du Moulinet D'Hardemare,Chemin,Vidal,Mathieu
, p. 3821 - 3828 (1996)
The new diisocyanide ligand L possessing a polyether backbone was synthesized and its complexing ability towards metal such as 99mTc, Cu and Re was evaluated. Using the γ-emitting 99mTc isotope (at the non-carrier added level), L led to the formation of a cationic species whose biodistribution in Swiss mice revealed a moderate but lasting heart uptake. No redox properties of the ligand were observed by complexation since reaction with a CuII salt led to the formation of a CuII complex, characterized by EPR, IR and elemental analysis. Rhenium complexation gave two new chelates [ReIIICl3PPh3L] and [ReI3]BPh4, identified by IR NMR, elemental analysis and conductimetric studies. The usefulness of rhenium chemistry to approach 99mTc properties is discussed. Copyright
