Synthesis and characterization of new diisocyanide rhenium complexes. Comparison with the homoleptic 99mTc complex

Article abstract of DOI:10.1016/0277-5387(96)00107-6

The new diisocyanide ligand L possessing a polyether backbone was synthesized and its complexing ability towards metal such as ^99mTc, Cu and Re was evaluated. Using the γ-emitting ^99mTc isotope (at the non-carrier added level), L led to the formation of a cationic species whose biodistribution in Swiss mice revealed a moderate but lasting heart uptake. No redox properties of the ligand were observed by complexation since reaction with a Cu^II salt led to the formation of a Cu^II complex, characterized by EPR, IR and elemental analysis. Rhenium complexation gave two new chelates [Re^IIICl₃PPh₃L] and [Re^I₃]BPh₄, identified by IR NMR, elemental analysis and conductimetric studies. The usefulness of rhenium chemistry to approach ^99mTc properties is discussed. Copyright