181869-00-1

Basic information

• Product Name: (2R,4S)-2-benzyl-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-(2-methoxyphenyl)pentanamide
• CAS NO: 181869-00-1
• Molecular Formula: C₂₈H₃₁NO₄
• Molecular Weight: 445.55
• Mol File: 181869-00-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 719.6°C at 760 mmHg
• Flash Point: 389°C
• Density: 1.23g/cm³
• Vapor Pressure: 9.89E-22mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: (2R,4S)-2-benzyl-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-(2-methoxyphenyl)pentanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-2-benzyl-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-(2-methoxyphenyl)pentanamide(181869-00-1)
• EPA Substance Registry System: (2R,4S)-2-benzyl-4-hydroxy-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-(2-methoxyphenyl)pentanamide(181869-00-1)

Safety Data

• Hazardous Substances Data: 181869-00-1(Hazardous Substances Data)

Upstream product

• 158512-24-4 (R)-2-Benzyl-1-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-3-(S)-oxiranyl-propan-1-one 
• 100-66-3 methoxybenzene 
• 194204-19-8 (2R,4S)-2-Benzyl-1-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3aH-indeno[1,2-d]oxazol-3-yl)-4-hydroxy-5-(2-methoxy-phenyl)-pentan-1-one 

Downstream Products

• 181868-99-5 (2R,4S)-2-Benzyl-4-hydroxy-5-(2-hydroxy-phenyl)-pentanoic acid ((1S,2R)-2-hydroxy-indan-1-yl)-amide 

Relevant articles and documents

Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN

A series of analogs of CRIXIVAN containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay.