181869-09-0Relevant articles and documents
Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN
Coburn, Craig A.,Young, Mary Beth,Hungate, Randall W.,Isaacs, Richard C.A.,Vacca, Joseph P.,Huff, Joel R.
, p. 1937 - 1940 (2007/10/03)
A series of analogs of CRIXIVAN containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay.