181872-32-2Relevant academic research and scientific papers
Asymmetric synthesis. 39. Synthesis of 2-(1-aminoalkyl)piperidines via 2-cyano-6-phenyl oxazolopiperidine
Froelich, Olivier,Desos, Patrice,Bonin, Martine,Quirion, Jean-Charles,Husson, Henri-Philippe,Zhu, Jieping
, p. 6700 - 6705 (2007/10/03)
The asymmetric synthesis of a series of 2-(1-aminoalkyl) piperidines using (-)-2-cyano-6-phenyloxazolopiperidine 1 is described. LiAlH4 reduction of 1 followed by hydrogenolysis led to the diamine 3. The same strategy applied to C-2-methylated
