1819-14-3

Basic information

• Product Name: (3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one
• Synonyms: (3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one;3β-Hydroxy-9β,10α-pregna-5,7-dien-20-one
• CAS NO: 1819-14-3
• Molecular Formula: C21H30O2
• Molecular Weight: 314.4617
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Steroids;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 1819-14-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one(1819-14-3)
• EPA Substance Registry System: (3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one(1819-14-3)

Safety Data

• Hazardous Substances Data: 1819-14-3(Hazardous Substances Data)

Usage

Uses

(3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one is used in the preparation of 10α-steroids.

Upstream product

• 28319-79-1 pregna-5,7-diene-3β-ol-20-one acetate 
• 1778-02-5 Pregnenolone acetate 
• 81968-78-7 3β-hydroxy-5,7-pregnadien-20-one 

Relevant articles and documents

Method and compound for synthetizing reprogestin

To the synthesis method, dehydropregnenolone is taken as a starting material, carbonyl-protected dehydropregnenolone is prepared, and then a methyl configuration overturning compound is obtained through photo-catalytic reaction and further subjected to deprotection. Hydroxylation and double bond rearrangement reaction yield progestin. The method has the advantages of easily available raw materials, high yield and simple and mild reaction conditions, and is suitable for industrial production of progestin.

Preparation method of dydrogesterone intermediate

The invention discloses a preparation method of a dydrogesterone intermediate. The preparation method is characterized by comprising the following steps: dissolving 5,7-diene steroid compound in an organic solvent to obtain a solution as a raw material; and carrying out a photocatalytic reaction and separating to obtain the dydrogesterone intermediate, wherein the 5,7-diene steroid compound is 7-dehydropregnenolone acetate, pregna-5,7-diene-3,20-diketodivinyl ketal, 7-dehydropregnenolone, ergosterol or pregna-5,7-diene-3,20-diketo-3-vinyl ketal, and a lamp used in the photocatalytic reaction comprises an LED ultraviolet lamp with the wavelength range of 295-335 nm. The preparation method of the dydrogesterone intermediate is high in yield, low in cost, safer in preparation and friendlier to environment.