81968-78-7

Basic information

• Product Name: 3-hydroxy-5,7-pregnadien-20-one
• Synonyms: 3-hydroxy-5,7-pregnadien-20-one;1-[(3S,9S,10R,13S,14R,17S)-3-hydroxy-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
• CAS NO: 81968-78-7
• Molecular Formula: C21H30O2
• Molecular Weight: 0
• Mol File: 81968-78-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 461.1°C at 760 mmHg
• Flash Point: 196.3°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 1.92E-10mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 3-hydroxy-5,7-pregnadien-20-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-5,7-pregnadien-20-one(81968-78-7)
• EPA Substance Registry System: 3-hydroxy-5,7-pregnadien-20-one(81968-78-7)

Safety Data

• Hazardous Substances Data: 81968-78-7(Hazardous Substances Data)

Usage

General Description

3-hydroxy-5,7-pregnadien-20-one, also known as 3-Hydroxy-5,7-pregnadien-20-one, is a chemical compound belonging to the steroid group. It is a derivative of pregnenolone and is a crucial intermediate in the biosynthesis of various hormones, including progesterone and cortisol. As a steroid hormone, it plays a significant role in various physiological processes such as metabolism, immune response, and stress regulation. 3-hydroxy-5,7-pregnadien-20-one is commonly used in the pharmaceutical industry for the production of synthetic hormones and corticosteroids, as well as in research for studying the endocrine system and hormone regulation.

InChI:InChI=1/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,15,17-19,23H,6-12H2,1-3H3/t15-,17+,18-,19-,20-,21+/m0/s1

Upstream product

• 1778-02-5 Pregnenolone acetate 
• 105186-40-1 3β-acetoxy-7α-bromo-pregn-5-en-20-one 
• 1639-44-7 3β-hydroxy-21-carboxy-pregn-5-en-20-ol 
• 1061-54-7 diosgenin acetate 
• 64110-65-2 (25R)-spirosta-5,7-dien-3β-ol acetate 
• 92008-96-3 7-bromo-(25R)spirosta-5,7-dien-3β-ol acetate 
• 64110-77-6 3β-acetoxy-5,7-pregnadien-20-one 4 phenyl-1,2,4-triazoline-3,5-dione salt 
• 105186-40-1 Acetic acid (3S,8S,9S,10R,13S,14S)-17-acetyl-7-bromo-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 28319-79-1 Acetic acid (3S,9S,10R,13S,14R)-17-acetyl-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 1093959-59-1 3β-hydroxypregn-5-en-20-one-3-acetate 
• 64110-59-4 (25R)-3β-acetoxy-31-phenyl-5α,8α-[1,2]epi[1,2,4]triazolo-spirost-6-ene-30,32-dione 
• 116028-16-1 3β-benzoyloxy-pregna-5,7-dien-20-one 
• 103281-96-5 3β-benzoyloxy-7α-bromo-pregn-5-en-20-one 
• 28319-79-1 pregna-5,7-diene-3β-ol-20-one acetate 

Downstream Products

• 601-33-2 dydrogesterone 
• 2691-68-1 3β-hydroxyandrosta-5,7-diene-17-one 
• 503313-27-7 3β,17α-dihydroxypregna-5,7-dien-20-one 
• 1819-14-3 pregnalumisterol 
• 28319-79-1 pregna-5,7-diene-3β-ol-20-one acetate 
• 116028-16-1 3β-benzoyloxy-pregna-5,7-dien-20-one 

Relevant articles and documents

Efficient Process for Preparing Steroids and Vitamin D Derivatives With the Unnatural Configuration at C20 (20 Alpha-Methyl) from Pregnenolone

Disclosed herein are methods for preparing steroids and Vitamin D derivatives having the unnatural beta (usually S) configuration at C20, the methods comprising the use of compounds of the formula: wherein R is as defined herein. Also disclosed are steroids and Vitamin D derivatives made using the methods disclosed herein and pharmaceutical compositions comprising said steroids and Vitamin D derivatives.

Structural modification of bioactive compounds. I. Syntheses of vitamin D analogues I

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