18193-40-3Relevant academic research and scientific papers
Novel anti-infection agents: Small-molecule inhibitors of bacterial transcription factors
Bowser, Todd E.,Bartlett, Victoria J.,Grier, Mark C.,Verma, Atul K.,Warchol, Taduesz,Levy, Stuart B.,Alekshun, Michael N.
, p. 5652 - 5655 (2008/02/13)
Structure-based drug design was utilized to identify potent small-molecule inhibitors of proteins within the AraC family of bacterial transcription factors, which control virulence in medically important microbes. These agents represent a novel approach to fight infectious disease and may be less likely to promote resistance development. These compounds lack intrinsic antibacterial activity in vitro and were able to limit a bacterial infection in a mouse model of urinary tract infection.
SUBSTITUTED QUINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACEUTICALPREPARATIONS
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, (2008/06/13)
Substituted quinoxalyl-imidazolidine-2,4-diones, processes for their preparation, their use as medicaments and pharmaceutical preparations 5-Quinoxalyl-imidazolidine-2,4-diones of the formula in which R 1, R 2, R 3, R 4 and R 5 have the meanings given, and physiologically tolerated salts thereof and processes for their preparation are described. The compounds inhibit aldose reductase and can be used as medicaments.
