181939-41-3Relevant academic research and scientific papers
Antimalarial sulfone trioxanes
Posner, Gary H.,O'Dowd, Hardwin,Caferro, Thomas,Cumming, Jared N.,Ploypradith, Poonsakdi,Xie, Suji,Shapiro, Theresa A.
, p. 2273 - 2276 (1998)
A series of new sulfide and sulfone 1,2,4-trioxanes was prepared in only a few steps from commercial reactants. The sulfone trioxanes were found to have higher in vitro antimalarial potencies than the sulfides, with 12β- arylsulfone trioxanes 1β being from 1/3 to 1/4 as potent as the complex natural antimalarial trioxane artemisinin (2). A tentative chemical mechanism is proposed to account for the great difference in antimalarial activity of the 12α- vs. 12β-sulfide trioxanes.
