181995-72-2Relevant academic research and scientific papers
Chemistry of the pyrrolo[1,2-a]benzimidazole antitumor agents: Influence of the 7-substituent on the ability to alkylate DNA and inhibit topoisomerase II
Zhou, Ru,Skibo, Edward B.
, p. 4321 - 4331 (2007/10/03)
This study addresses the influence the 7-substituent on the cytotoxicity of pyrrolo[1,2-a]benzimidazole quinones possessing a 6-aziridinyl group (PBIs) and a 6-acetamido group (APBIs). Reduction of a PBI to the aziridinyl hydroquinone results in both nucl
