181997-02-4

Basic information

• Product Name: 3-fluoro-1-nitro-4-(1H-pyrrol-1-yl)benzene
• Synonyms: 3-fluoro-1-nitro-4-(1H-pyrrol-1-yl)benzene
• CAS NO: 181997-02-4
• Molecular Weight: 206.176
• Mol File: 181997-02-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-fluoro-1-nitro-4-(1H-pyrrol-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-1-nitro-4-(1H-pyrrol-1-yl)benzene(181997-02-4)
• EPA Substance Registry System: 3-fluoro-1-nitro-4-(1H-pyrrol-1-yl)benzene(181997-02-4)

Safety Data

• Hazardous Substances Data: 181997-02-4(Hazardous Substances Data)

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 369-35-7 2-fluoro-4-nitroaniline 
• 109-97-7 pyrrole 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 1542257-88-4 3-(3-fluoro-4-(1H-pyrrol-1-yl)phenyl)-2,6-dimethylpyrimidin-4(3H)-one 
• 909015-13-0 Methanesulfonic acid (R)-3-(3-fluoro-4-pyrrol-1-yl-phenyl)-2-oxo-oxazolidin-5-ylmethyl ester 
• 226220-33-3 (R)-5-Azidomethyl-3-(3-fluoro-4-pyrrol-1-yl-phenyl)-oxazolidin-2-one 
• 181997-03-5 3-fluoro-1-(phenylmethoxycarbonylamino)-4-(1H-pyrrol-1-yl)benzene 
• 226220-32-2 (5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methanol 
• 343880-90-0 (5S)-[N-3-(3'-fluoro-4'-(1(H)-pyrrolyl)phenyl)-2-oxo-5-oxazolidinyl]methylamine 
• 1026976-95-3 3-fluoro-4-(1H-pyrrol-1-yl)aniline 

Relevant articles and documents

Novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application (by machine translation)

The invention relates to the general formula I shown novel substituted benzoyl compound and its pharmaceutically acceptable salt and preparation method and application. The invention also provides pharmaceutical compositions containing them, in vitro and in vivo anti-tumor effect results and acute toxicity study, the obtained anti-tumor drug model substituted benzoyl compound, has more excellent anti-tumor activity and safety, can be in the treatment of leukemia, lung cancer, colon cancer, ovarian cancer and renal carcinoma tumor in the application, so that the therapeutic window, so in the medical field as antitumor agents in the very application value. (by machine translation)

Substituted indolinone derivative and application thereof

The invention relates to a substituted indolinone derivative represented as the general formula (I) and used as a tyrosine kinase inhibitor, and medicinal acceptable salts or isomers thereof, wherein the R1, R2, R3, R4, R5, R6, R7, n and the ring A are defined as the specifications. The invention also relates to a preparation method of the compound, and an application of the compound in preparation of medicines for prevention or therapy of fibrosis diseases and excess hyperplasia diseases.

NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS

The present invention relates to the field of medicine, provided herein are novel nitrogenous heterocyclic compounds, their preparation methods and their uses as drugs, especially for treatment and prevention of tissue fibrosis. Also provided herein are pharmaceutically acceptable compositions comprising the nitrogenous heterocyclic compounds and the uses of the compositions in the treatment of human or animal tissue fibrosis, especially for human or animal renal interstitial fibrosis, glomerular sclerosis, liver fibrosis, pulmonary fibrosis, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, postsurgical adhesion, benign prostatic hyperplasia, skeletal muscle fibrosis, scleroderma, multiple sclerosis, pancreatic fibrosis, cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, diabetic nephropathy, alzheimer disease or vascular fibrosis.