41680-34-6 Usage
Description
3-Aminopyrazole-4-carboxylic acid is a heterocyclic building block that serves as a key component in the synthesis of more complex pharmaceutical and biologically active compounds, including inhibitors. Its unique structure allows it to be a versatile component in the development of various drugs and therapeutic agents.
Uses
Used in Pharmaceutical Industry:
3-Aminopyrazole-4-carboxylic acid is used as a synthetic intermediate for the development of complex pharmaceutical compounds. Its ability to form stable bonds with other molecules makes it a valuable asset in the creation of new drugs and therapeutic agents.
Used in Biologically Active Compounds Synthesis:
3-Aminopyrazole-4-carboxylic acid is used as a building block for the synthesis of biologically active compounds, which have potential applications in various fields such as medicine, agriculture, and environmental science.
Used in Preparation of Impurities and Degradation Products:
3-Aminopyrazole-4-carboxylic acid is used for the preparation of some impurities and/or degradation products of Zaleplon (Z145000), a sedative-hypnotic drug used for the short-term treatment of insomnia.
Used in Arylsulfonamidopiperidone Derivatives Synthesis:
3-Aminopyrazole-4-carboxylic acid is used in the synthesis of Arylsulfonamidopiperidone derivatives, which represent a novel class of factor Xa inhibitors. These inhibitors have potential applications in the treatment of various thrombotic disorders and are being actively researched for their therapeutic potential.
Check Digit Verification of cas no
The CAS Registry Mumber 41680-34-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,6,8 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 41680-34:
(7*4)+(6*1)+(5*6)+(4*8)+(3*0)+(2*3)+(1*4)=106
106 % 10 = 6
So 41680-34-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H5N3O2/c5-3-2(4(8)9)1-6-7-3/h1H,(H,8,9)(H3,5,6,7)
41680-34-6Relevant articles and documents
Design of pyrazolo-pyrimidines as 11β-HSD1 inhibitors through optimisation of molecular electrostatic potential
Robb, Graeme R.,Boyd, Scott,Davies, Christopher D.,Dossetter, Alexander G.,Goldberg, Frederick W.,Kemmitt, Paul D.,Scott, James S.,Swales, John G.
supporting information, p. 926 - 934 (2015/05/27)
The inhibition of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a potentially attractive mechanism for the treatment of obesity and other elements of the metabolic syndrome. A series of pyrazolo-pyrimidine inhibitors of this enzyme were identified from directed library synthesis. Knowledge of how these compounds bind to the enzyme and the key hydrogen-bonding interactions was used to design further compounds. The hydrogen-bond acceptor strength was calculated from the molecular electrostatic potential using quantum mechanical theory. Compounds were designed to modulate the acceptor strength, thus optimising the potency and other drug-like properties. Compounds with enhanced CNS penetration were designed through further modification of the electrostatic potential and the hydrogen-bond properties.