182000-03-9

Upstream product

• 7050-16-0 tris(4-t-butylphenyl)methyl chloride 
• 181999-90-6 1-((2R,4S,5R)-4-{3-[(2R,3S,5R)-3-Hydroxy-5-(4-hydroxy-5-methyl-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-prop-2-ynyloxy}-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione 
• 181999-83-7 1-(2,5,6-trideoxy-6,6-dibromo-3-O-(tert-butyldiphenylsilyl)-β-D-erythro-hex-5-enofuranosyl)-5-methyluracil 
• 181999-85-9 1-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(3-hydroxy-prop-1-ynyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Replacement of the phosphodiester linkage in oligonucleotides by an acetylenic bond: Comparison between carbon-, sulfur-, and oxygen-containing analogs

Four acetylene-containing dimers were synthesized and incorporated into oligonucleotides. The hybridization properties of the modified oligonucleotides to RNA complements and their conformational analysis are reported.