181999-83-7

Upstream product

• 558-13-4 carbon tetrabromide 
• 146604-43-5 1-(2-deoxy-3-O-tert-butyldiphenylsilyl-β-D-erythro-pentadialdo-1,4-furanosyl)-5-methyluracil 
• 83467-48-5 1-[(2R,4S,5R)-4-(tert-butyldiphenylsilanyloxy)-5-hydroxymethyltetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 50-89-5 thymidine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 56506-90-2 (dibromomethyl)(triphenyl)phosphonium bromide 
• 289681-49-8 1-[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-{[(1,1-dimethylethyl)diphenylsilyl]oxy}tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione 
• 40733-28-6 5'-tert-butyldimethylsilyloxy-2'-deoxythymidine 

Downstream Products

• 181999-85-9 1-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-(3-hydroxy-prop-1-ynyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 
• 236754-84-0 (E)-6'-bromo-(5'-deoxy-5'-methylidene)-3'-O-(tert-bytuldiphenylsilyl)thymidine 
• 1210349-14-6 C₂₇H₃₀N₂O₄Si 
• 1262311-81-8 1-[(2R,4S,5S)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-(4-{(2R,3S,5R)-3-hydroxy-5-[5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-2-yl}-1H-1,2,3-triazol-1-yl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione 
• 1262311-78-3 (2R,3S,5R)-2-({1-[(2S,3S,5R)-2-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-5-[5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-3-yl]}-1H-1,2,3-triazol-4-yl)-5-[5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite 
• 1315117-20-4 1-(3'-deoxy-5'-O-(4,4'-dimethoxytrityl)thimidine-3'-yl)-4-(3'-O-(tert-butyldiphenylsilyl)-4'-de(hydroxymethyl)thymidine-4'-yl)-1H-1,2,3-triazole 
• 181999-94-0 C₆₉H₈₂N₄O₈SSi 
• 181999-95-1 C₅₃H₆₄N₄O₈S 
• 182000-03-9 C₅₃H₆₄N₄O₉ 
• 181999-92-8 1-[(2R,4S,5R)-5-(3-Bromo-prop-1-ynyl)-4-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis and Properties of Oligonucleotides Having Ethynylphosphonate Linkages

Ethynylphosphonate (EP)-linked thymidine dimers were synthesized via a palladium-catalyzed cross-coupling reaction and successfully incorporated into oligonucleotides. The oligonucleotides containing EP linkages appropriately formed a duplex with their complementary single-stranded RNA (ssRNA) and single-stranded DNA. The oligonucleotides containing both the EP linkages and 2′-O,4′-C-methylene-bridged nucleic acid/locked nucleic acid exhibited strong duplex-forming ability toward the complementary ssRNA. The EP-modified oligonucleotides exhibited higher exonuclease resistances than their natural counterparts. Moreover, one EP modification to a gapmer-type antisense oligonucleotide resulted in a switch of the cleavage site in the target ssRNA. Therefore, the EP modification can be applied for controlling the cleavage site in the RNase H-dependent mechanism.

Synthesis and hybridization data of oligonucleotide analogs with triazole internucleotide linkages, potential antiviral and antitumor agents

Triazolyl-functionalized oligonucleotide (ON) analogs have received much attention as potential antitumor and antiviral agents. The most promising of such analogs are those exhibiting high binding affinity toward native DNA/RNA, since they may prove to be

Commercially available 5'-DMT phosphoramidites as reagents for the synthesis of vinylphosphonate-linked oligonucleic acids.

[reaction: see text]. Commercially available cyanoethyl phosphoramidites derived from T, d(C), d(A), and d(G) were hydrolyzed (1H-tetrazole, MeCN/H2O) to give the corresponding H-phosphonates in excellent yields. Palladium(0)-catalyzed cross-coupling of e

A novel palladium-catalysed coupling strategy for the rapid synthesis of nucleic acid analogues bearing modified backbones

The synthesis of a 5'-deoxy-5'-methylidene phosphonate-containing thymidine dimer 14 has been achieved using a palladium-catalysed cross coupling reaction as a key step. The E-vinyl bromide 9 was synthesised from the corresponding 1,1-dibro-moolefin 7 via