182004-65-5 Usage
Uses
Used in Pharmaceutical Industry:
2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE is used as a research compound for investigating its potential pharmacological properties and applications. Its unique structure may allow it to interact with specific biological targets, making it a candidate for the development of new drugs or therapies.
Used in Chemical Research:
In the field of chemical research, 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE can be used as a starting material or intermediate for the synthesis of other complex organic molecules. Its versatile structure may enable the development of new compounds with various applications in different industries.
Used in Material Science:
The unique properties of 2-[2-[4-(4-NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA MESYLATE may also find applications in material science, where it could be used to develop new materials with specific properties, such as improved conductivity, stability, or reactivity.
Biological Activity
Potent, selective inhibitor of the reverse mode of the Na + /Ca 2+ exchanger (IC 50 = 0.7 mM). Does not affect Na + -dependent transport systems, Na + channels or ionotropic glutamate receptors.
Biochem/physiol Actions
Target IC50: 4.3 μM, 4.7 μM, and 1.4 μM for NCX1,NCX2, and NCX3, respectively
References
1) Iwamoto et al. (1996), Novel Isothiourea Derivative Selectively Inhibits the Reverse Mode of Na+/Ca2+ Exchange in Cells Expressing NCX1; J. Biol .Chem., 271 22391
2) Hoyt et al. (1998) Reverse Na+/Ca2+ exchange contributes to glutamate-induced intracellular Ca2+ concentration increases in cultured rat forebrain neurons; Mol. Pharmacol., 53 742
3) Santo-Domingo et al. (2007) The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter; Br. J. Pharmacol., 151 647
4) Brustovetsky et al. (2011) KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I; Br. J. Pharmacol,. 162 255
Check Digit Verification of cas no
The CAS Registry Mumber 182004-65-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,2,0,0 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 182004-65:
(8*1)+(7*8)+(6*2)+(5*0)+(4*0)+(3*4)+(2*6)+(1*5)=105
105 % 10 = 5
So 182004-65-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
