18202-52-3

Upstream product

• 18202-49-8 6-(morpholin-4-yl)-5-nitrosopyrimidine-2,4-diamine 
• 77287-34-4 formamide 
• 110-91-8 morpholine 
• 10310-21-1 2-Amino-6-chloropurin 

Relevant academic research and scientific papers

Design, synthesis and activity of novel 2,6-disubstituted purine derivatives, potential small molecule inhibitors of signal transducer and activator of transcription 3

Sustained activation of STAT3 is closely related to the cancer development, but the inhibitors for STAT3 overexpression are still in the clinical research stage. In this study, a series of 2,6-disubstituted purine derivatives were designed and synthesized

2-Amino-purine derivative compound, preparing method and use thereof

According to one aspect, provided are a purine compound, a stereoisomer, a derivative, a solvate, or a pharmaceutically acceptable salt thereof, a manufacturing method thereof and uses thereof. According to the same, the compound, and the stereoisomer, derivative, solvate, or pharmaceutically acceptable salt thereof have low cytotoxicity, and exhibit high selective inhibitory activity against HSP90, and antiproliferative effect of cancer cells, thereby being useful for preventing or treating cancer.(AA) Density(BB) Compound(CC) andbeta;- tubulinCOPYRIGHT KIPO 2018

An efficient synthesis of substituted cytosines and purines under focused microwave irradiation

A rapid nucleophilic displacement reaction of 6-chloropurine, 2-amino-6-chloropurine and 5-bromocytosine with various nucleophiles under focused microwave irradiation is described. Using this method, the desired products were obtained with the yields up to 99% in?a?short reaction time.