18203-05-9Relevant academic research and scientific papers
Identification of co-mutagenic chlorinated harmans in final effluent from a sewage treatment plant
Fukazawa, Hitoshi,Matsushita, Hidetsuru,Terao, Yoshiyasu
, p. 65 - 70 (2001)
Harman (1-methyl-9H-pyrido[3,4-b]indole) reacted readily with sodium hypochlorite in an aqueous medium to give the mono-chlorinated derivatives, which reportedly have greater co-mutagenic activity than harman in the presence of o-toluidine toward Salmonella typhimurium TA 98 with S9 mix. Mono-chlorinated harmans were detected by concentration using blue rayon (BR) and GC/MS analysis in the final effluent from a sewage treatment plant in Shizuoka, Japan. The amounts adsorbed for 24h were 1-45ng/gBR for mono-chlorinated harman and 110-730ng/gBR for harman.
