182055-83-0

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 

Downstream Products

• 1345019-52-4 (1S,1′R)-(-)-6,7-dimethoxy-2(1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline-1-carbonitrile 
• 1345019-57-9 (1S)-(-)-1-(2-(1,3-dioxolan-2-yl)ethyl)-6,7-dimethoxy-2-[(1S)-1-phenylethyl]-1,2,3,4-tetrahydroisoquinoline 
• 1443828-69-0 (R)-6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-1,2,3,4-tetrahydroisoquinoline 
• 1443828-67-8 (R)-6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-2-((R)-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline 
• 1443828-65-6 (R)-N-(3,4-dimethoxyphenylethyl)-2-(4-methoxyphenoxy)-N-(1-phenylethyl)acetamide 
• 1443828-63-4 (R)-2-chloro-N-(3,4-dimethoxyphenylethyl)-N-(1-phenylethyl)acetamide 
• 1443828-71-4 (R)-(3-chlorophenyl)(6,7-dimethoxy-1-((4-methoxyphenoxy)methyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone 
• 38974-83-3 (R)-(+)-noranicanine 
• 182055-88-5 (R)-(+)-[2-(3,4-dimethoxyphenyl)ethyl](1-phenylethyl)amine 

Relevant academic research and scientific papers

Synthesis and structure activity relationship of tetrahydroisoquinoline- based potentiators of GluN2C and GluN2D containing N-Methyl-D-aspartate receptors

We describe here the synthesis and evaluation of a series of tetrahydroisoquinolines that show subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. Bischler-Napieralski conditions were employed in the key step for the

Electrochemical synthesis and chemistry of chiral 1- cyanotetrahydroisoquinolines. An approach to the asymmetric syntheses of the alkaloid (-)-crispine A and its natural (+)-antipode

The stereoselective convergent total syntheses of both enantiomers of the tetrahydroisoquinoline (THIQ) alkaloid crispine A are described. The THIQ precursors ( - )-6 (90:10 dr) and ( - )-11 (85:15 dr) were prepared from the alkylation - reduction sequenc

Enantioselective syntheses and X-ray structures of (S)- and (R)-N-norlaudanidine: trace opium constituents

The enantioselective synthesis of each of the enantiomers of N-norlaudanidine, a minor Papaver somniferum opium benzyltetrahydoisoquinoline alkaloid is described. This was achieved using a chiral auxiliary-mediated Bischler-Napieralski cyclization-sodium borohydride reduction strategy. The X-ray crystal structures of each of these secondary amines are reported.

Asymmetric synthesis of (R)-(+)-noranicanine

Optically active (R)-(+)-noranicanine (1) was synthesized via stereoselective reduction of the corresponding iminium ion possessing a chiral auxiliary by Polniaszek's method.